SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,nucleus
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text
| N-linked glycosylation of perforin was critical for transport from the Golgi to secretory granules ![](pubmed.jpg) |
basic FUNCTION
| crucial effector of T and NK cell-mediated cytolysis |
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plays a key role in immune surveillance and immune homeostasis ![](pubmed.jpg) |
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involved in down regulation of cellular immune activation |
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involved in cell-mediated cytotoxicity ![](pubmed.jpg) |
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pore-forming protein engaged mainly in mediating target T cell death and is employed by cytotoxic T lymphocytes (CTLs) and natural killer cells ![](pubmed.jpg) |
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plays a negative role in regulating CD4(+) T cell activation and immune response by affecting TCR-dependent Ca(2+) signaling ![](pubmed.jpg) |
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its permeabilizing activity, but not binding to lipid membranes, is affected by pH ![](pubmed.jpg) |
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oligomerizes to form pores that deliver the pro-apoptopic granzymes into the cytosol of the target cell ![](pubmed.jpg) |
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forms heterogeneous pores through a multistep mechanism ![](pubmed.jpg) |
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PRF1-dependent cytotoxicity has an immunoregulatory role that is distinguishable from its pathogen clearance function and limits T-cell activation in the physiologic context by suppressing antigen presentation ![](pubmed.jpg) |
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rapidly induces plasma membrane phospholipid flip-flop ![](pubmed.jpg) |
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FCGR3A and PRF1 may participate in the pathogenesis and progression of primary biliary cirrhosis (PBC) |
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