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FLASH GENE
Symbol PREX2 contributors: mct/npt - updated : 24-05-2016
HGNC name phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
HGNC id 22950
Location 8q13.2      Physical location : 68.864.602 - 69.143.897
Synonym name
  • hypothetical protein FLJ12987
  • phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 2
  • PtdIns(3,4,5)-dependent Rac exchanger 2
  • protein phosphatase 1, regulatory subunit 129
  • DEP domain containing 2
  • Synonym symbol(s) DEP.2, FLJ12987, 6230420N16Rik, P-Rex2, PtdIns, DEPDC2, PPP1R129
    DNA
    TYPE functioning gene
    STRUCTURE 279.58 kb     40 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    40 - 5132 182.6 1606 . widely but not in leukocytes . more abundant in human cancer cells and significantly increased in tumors with wild-type PTEN 2009 19729658
  • variant 1 or P-REX2a
  • inhibited PTEN lipid phosphatase activity and stimulated the PI3K pathway only in the presence of PTEN
  • is a component of the PI3K pathway that can antagonize PTEN in cancer cells
  • 24 - 3024 - 979 only in the heart 2014 24367090
  • variant 2 or P-REX2b
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Nervousbrainhindbraincerebellum  
    Reproductivefemale systembreastmammary gland  
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a catalytic Dbl homology domain followed invariably by a lipid-binding pleckstrin homology (PH) domain
  • HOMOLOGY
    Homologene
    FAMILY
  • P-Rex family of Rac-GEFs proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • guanine-nucleotide exchange factor, activating the small GTPase Rac
  • may serving as a novel link between Rac activation and the PI-3 kinase pathway
  • important regulator of Purkinje cell morphology and cerebellar function
  • functional role for PREX2 PH-domain-mediated inhibition of PTEN in regulating insulin sensitivity and glucose homeostasis, suggesting that loss of PREX2 expression may cause insulin resistance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PTEN-interacting protein and negative regulator of PTEN in breast cancer
  • CXCL9 was involved in the invasion ability of hepatocellular carcinoma possibly through up-regulation of its potential effector PREX2
  • guanine nucleotide exchange factor (GEF) for RAC1 GTPase, facilitating the exchange of GDP for GTP on RAC1
  • RAC1 initiates its own inactivation by decreasing PREX2 GEF activity
  • reciprocal regulation of PREX2 by PTEN whereby loss of PTEN results in a dramatic increase in expression of PREX2 at the protein level
  • cell & other
    REGULATION
    Other regulated by phosphatidylinositol (3,4,5)-trisphosphate and the beta gamma subunits of heterotrimeric G proteins
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    somatic mutations generate truncated or variant proteins that gain oncogenic activity in melanoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • is a candidate melanoma gene whose amplifications, rearrangements or mutations appeared to undergo positive selection in human melanoma genesis
  • Marker
    Therapy target
    ANIMAL & CELL MODELS