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FLASH GENE
Symbol PREX1 contributors: mct - updated : 08-03-2012
HGNC name phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
HGNC id 32594
Location 20q13.13      Physical location : 47.240.792 - 47.444.420
Genatlas name phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1
Synonym name
  • KIAA1415 protein
  • PI 3,4,5-trisphosphate[PI(3,4,5)P3; PIP3]-dependent Rac exchanger 1 (P-Rex1)
  • Synonym symbol(s) KIAA1415, P-Rex1
    DNA
    TYPE like-sequence
    STRUCTURE 203.63 kb     40 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    40 - 6633 186 1659 - 2007 17698854
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     spleen   highly
     tonsils   highly
    Nervousnerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • Dbl homology/pleckstrin homology domain tandem sufficient for synergistic Gbetagamma- and PI3K-driven membrane localization
  • DEP, PDZ, and IP4P domains contributing to keeping the enzyme localized in the cytosol of basal cells
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text
  • membrane translocation is mediated by G protein betagamma subunits and phosphoinositide 3-kinase
  • association with membranes is a prerequisite for cellular activation
  • basic FUNCTION
  • acting as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs)
  • serves as an important regulator of neutrophil NADPH oxidase activity and chemotaxis in response to a variety of extracellular stimuli
  • RAC1-specific guanine nucleotide exchange factor abundant in neutrophils and myeloid cells
  • serves as an important regulator of human neutrophil NADPH oxidase activity and chemotaxis in response to a variety of extracellular stimuli
  • promotes membrane ruffling and cell migration in response to Rac activation
  • RAC3-GEF in neuronal cells that localises to, and regulates, actin cytoskeletal dynamics at the axonal growth cone to in turn regulate neurite differentiation
  • plays an important role in signaling downstream of neutrophil chemoattractant receptors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind to and activate RAC1 by exchanging bound GDP for free GTP
  • crosstalk between the PREX1-Rac pathway and AKT1 in superoxide generation
  • activation of AKT1 through CRTC2 and PREX1, that regulates cancer cell migration, invasion and metastasis)
  • HDAC1 and HDAC2 could regulate PREX1 gene transcription by interaction with Sp1 and by region-specific changes in histone acetylation within the PREX1 promoter
  • cell & other
    REGULATION
    activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins (may act as a coincidence detector for these signaling molecules)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    expression was much higher in metastatic prostate cancer cells than in prostate epithelial cells and non-metastatic prostate cancer cells, with epigenetic regulation by HDAC1 and HDAC2
    tumoral     --over  
    highly overexpressed in breast cancers and their derived cell lines, particularly those with high ERBB2 expression
    Susceptibility type 2 diabetes mellitus
    Variant & Polymorphism SNP associated with the risk of type 2 diabetes mellitus
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    PREX1 targeting may be therapeutically relevant in breast cancer
    ANIMAL & CELL MODELS