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FLASH GENE
Symbol PREP contributors: mct/npt - updated : 03-07-2008
HGNC name prolyl endopeptidase
HGNC id 9358
Location 6q22      Physical location : 105.725.441 - 105.850.999
Synonym name
  • post-proline cleaving enzyme
  • prolyl oligopeptidase
  • dJ355L5.1 (prolyl endopeptidase)
  • Synonym symbol(s) MGC16060, PE, PEP, POP
    EC.number 3.4.21.26
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 125.00 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389419 6 similar to hypothetical protein (L1H 3 region) - human LOC391956 6 similar to Hypothetical protein KIAA1002 HACE1 6q21 HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 LOC389420 6 LOC389420 LOC389421 6 similar to LOC373796 protein BVES 6q21 blood vessel epicardial substance POPDC3 6q21 popeye domain containing 3 PREP 6q16.3-q21 prolyl endopeptidase LOC391957 6 similar to Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60) PRDM1 6q21-q22.1 PR domain containing 1, with ZNF domain APG5L 6q21 APG5 autophagy 5-like (S. cerevisiae) AIM1 6q21 absent in melanoma 1 RTN4IP1 6q21 reticulon 4 interacting protein 1 QRSL1 6q21 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 C6orf203 6q21 chromosome 6 open reading frame 203 KIAA1553 6q21 KIAA1553 C6orf210 6q21 chromosome 6 open reading frame 210 FLJ10159 6q21 hypothetical protein FLJ10159 SCML4 6q21 sex comb on midleg-like 4 (Drosophila) SEC63 6q21 SEC63-like (S. cerevisiae) LOC285752 6q21 similar to ribosomal protein L3; 60S ribosomal protein L3; HIV-1 TAR RNA-binding protein B OSTM1 6q21 osteopetrosis associated transmembrane protein 1 NR2E1 6q21 nuclear receptor subfamily 2, group E, member 1 SNX3 6q13-q22.3 sorting nexin 3 LACE1 6q22.1 lactation elevated 1 FOXO3A 6q21 forkhead box O3A LOC391958 6 similar to zinc finger protein 259; zinc finger protein ZPR1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2849 80 710 - Myohanen (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
     stomach   highly
    Endocrineneuroendocrinepituitary  highly
    Nervousbrainbasal nucleicaudate nucleus   Homo sapiens
     brainbasal nucleiputamen   Homo sapiens
    Reproductivefemale systembreastmammary gland highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase S9A family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text also membrane-bound form in brain
    basic FUNCTION
  • prolyl oligopeptidase, serine endopeptidase activity
  • playing a role in movement regulation, cognition and possibly in inositol 1,4,5-triphosphate signaling
  • having a functions in axonal transport and/or protein secretion
  • participate in regulating the levels of seminal TRH analogues and in mediating sperm death associated with necrozoospermia
  • serine protease that cleaves small peptides at the carboxyl side of an internal proline residue
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS