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FLASH GENE
Symbol PREP contributors: mct/npt - updated : 03-07-2008
HGNC name prolyl endopeptidase
HGNC id 9358
Location 6q22      Physical location : 105.725.441 - 105.850.999
Synonym name
  • post-proline cleaving enzyme
  • prolyl oligopeptidase
  • dJ355L5.1 (prolyl endopeptidase)
  • Synonym symbol(s) MGC16060, PE, PEP, POP
    EC.number 3.4.21.26
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 125.00 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2849 80 710 - Myohanen (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
     stomach   highly
    Endocrineneuroendocrinepituitary  highly
    Nervousbrainbasal nucleicaudate nucleus   Homo sapiens
     brainbasal nucleiputamen   Homo sapiens
    Reproductivefemale systembreastmammary gland highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase S9A family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text also membrane-bound form in brain
    basic FUNCTION
  • prolyl oligopeptidase, serine endopeptidase activity
  • playing a role in movement regulation, cognition and possibly in inositol 1,4,5-triphosphate signaling
  • having a functions in axonal transport and/or protein secretion
  • participate in regulating the levels of seminal TRH analogues and in mediating sperm death associated with necrozoospermia
  • serine protease that cleaves small peptides at the carboxyl side of an internal proline residue
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS