Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PRELP contributors: mct/npt - updated : 24-12-2013
HGNC name proline arginine-rich end leucine-rich repeat protein
HGNC id 9357
Location 1q32.1      Physical location : 203.444.882 - 203.460.477
Synonym name
  • 55 kDa leucine-rich repeat protein of articular cartilage
  • prolargin
  • prolargin proteoglycan
  • 55 kDa leucine-rich repeat protein of articular cartilage
  • Synonym symbol(s) PRLP, MST161, MSTP161, SLRR2A, MGC45323
    DNA
    TYPE functioning gene
    STRUCTURE 15.60 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - LRPPRC - SLC3A1 - PREPL - C2orf34 - SIX3 - cen
    Authors Martens (2007)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 5833 43.8 382 - 2002 11847210
    3 codon stop 5823 - 382 - 2002 11847210
    extended 3'utr
    - - - 38 - - 2013 23826326
  • unique expression of a 38 kDa PRELP in chronic lymphocytic leukemia (CLL) cells may suggest involvement in the pathobiology of CLL
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyesclera  highly Homo sapiensAdult
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly Homo sapiensFetal
    Connectivecartilage  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificchondrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • basic N terminal ARG/PRO-rich binding domain
  • a heparin-binding N terminus has been shown to have antimicrobial activity
  • a GAG-binding domain ((hbd)
  • 10 characteristic leucine-rich repeats flanked by cysteine loops in both the N and C termini
  • a N-linked glycosylation site (NKSIT motifs) in the LRR region
  • a putative secretory signal sequence and several glycosylation sites
  • HOMOLOGY
    interspecies homolog to murine Prelp
    intraspecies homolog to FMOD
    Homologene
    FAMILY
  • small leucine-rich proteoglycan (SLRP) family
  • class II subfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    text
  • cuticle, basement membrane
  • localize to the physis (Shapiro 2009)
  • normally expressed in extracellular matrix of collagen-rich tissues
  • basic FUNCTION
  • functions as a molecule anchoring basement membranes to the underlying connective tissue
  • maybe anchoring basement membrane to the underlying connective tissue
  • playing a role in skeletal development
  • may play a critical role in regulating the biomechanical properties of scleral extracellular matrix
  • glycosaminoglycan (GAG)- and collagen-binding anchor protein, acting as a cell type-specific NF-kappaB inhibitor that impairs osteoclastogenesis
  • most upregulated gene in the physeal region (Shapiro 2009)
  • inhibits the formation of the membrane attack complex and thereby inhibits all three pathways of complement
  • may act as a local complement inhibitor at basement membranes or at sites with exposed cartilage
  • may down-regulate complement attack at basement membranes and on damaged cartilage and therefore limit pathological complement activation in inflammatory disease such as rheumatoid arthritis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS ossification
    PATHWAY
    metabolism
    signaling
    a component
  • constituent matrix protein of articular cartilage, 55 kDa
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds the basement membrane heparan sulfate proteoglycan perlecan
  • binds triple helical collagens type I and type II
  • interact with the complement inhibitor C4B-binding protein, C4BPB, and C4BPA
  • inhibits the assembly of the alternative C3-convertase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    perturbed organization of collagen fibrils in the dermis and the thickness of the hypodermal fat layer was diminished
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS