basic FUNCTION
| functions as a molecule anchoring basement membranes to the underlying connective tissue |
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maybe anchoring basement membrane to the underlying connective tissue |
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playing a role in skeletal development |
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may play a critical role in regulating the biomechanical properties of scleral extracellular matrix |
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glycosaminoglycan (GAG)- and collagen-binding anchor protein, acting as a cell type-specific NF-kappaB inhibitor that impairs osteoclastogenesis |
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most upregulated gene in the physeal region (Shapiro 2009) |
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inhibits the formation of the membrane attack complex and thereby inhibits all three pathways of complement |
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may act as a local complement inhibitor at basement membranes or at sites with exposed cartilage |
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may down-regulate complement attack at basement membranes and on damaged cartilage and therefore limit pathological complement activation in inflammatory disease such as rheumatoid arthritis |