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FLASH GENE
Symbol PREB contributors: mct/npt - updated : 03-07-2008
HGNC name prolactin regulatory element binding
HGNC id 9356
Location 2p23      Physical location : 27.353.624 - 27.357.542
Synonym name mammalian guanine nucleotide exchange factor mSec12
Synonym symbol(s) SEC12, MGC3467
DNA
TYPE functioning gene
SPECIAL FEATURE overlapping
text
  • with ABHD1 contain a conserved 42 bp overlap in their 3'UTR, and share a conserved TTTATTAAA/TTTAATAAA sequence that serves as a polyadenylation signal for both genes
  • STRUCTURE 3.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    motif
    text structure
  • IP (PIT-J binding element)
  • a single polyadenylation signal, AATAAA, within the 3'UTR
  • MAPPING cloned Y linked N status provisional
    Physical map
    FLJ20555 CENPA 2p23.1-p22.3 centromere protein A, 17kDa DPYSL5 2p23-p21 dihydropyrimidinase-like 5 MAPRE3 2p23.3-p23.1 microtubule-associated protein, RP/EB family, member 3 FLJ20254 2p23.3 hypothetical protein FLJ20254 FLJ21839 2p23.3 hypothetical protein FLJ21839 EMILIN1 2p23.3-p23.2 elastin microfibril interfacer 1 KHK 2p23.3-p23.2 ketohexokinase (fructokinase) CGREF1 2p23.3 cell growth regulator with EF hand domain 1 ABHD1 2p23.3 abhydrolase domain containing 1 PREB 2p23 prolactin regulatory element binding MGC44505 2p23.3 hypothetical protein MGC44505 LOC391360 2 similar to class II basic helix-loop-helix protein TCF23 SLC5A6 2p23 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 APR-3 2p23.3 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 CAD 2p22-p21 carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase SLC30A3 2p23.3 solute carrier family 30 (zinc transporter), member 3 FLJ40417 2p23.3 gamma cysteine string protein RNF30 2p23.3 ring finger protein 30 UCN 2p23-p21 urocortin MPV17 2p23 MpV17 transgene, murine homolog, glomerulosclerosis GTF3C2 2p23.3 general transcription factor IIIC, polypeptide 2, beta 110kDa EIF2B4 2p23.3 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa SNX17 2p23-p22 sorting nexin 17 ZNF513 2p23.3 zinc finger protein 513 PPM1G 2p33.3 protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform NRBP 2p23 nuclear receptor binding protein KCP3 SLB 2p23.3 selective LIM binding factor, rat homolog FRCP1 GCKR 2p23.3-p23.2 glucokinase (hexokinase 4) regulatory protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2211 45 417 - Edgar (2003)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     salivary gland   highly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text surface ectoderm, developing liver, Rathke's pouch, skeleton
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • highly conserved WD repeat domain
  • two PQ rich potential transactivation domains but no apparent DNA binding motif
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,nucleus
    basic FUNCTION
  • prolactin regulatory element binding
  • transcriptional regulator role both in the pituitary and in other organs in which transcripts of its gene are expressed
  • promotes efficient guanine nucleotide exchange on the IQGAP1 GTPase in the endoplasmic reticulum
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mediating transcriptional activation of PRKA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS