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FLASH GENE
Symbol PRDX1 contributors: mct - updated : 03-11-2016
HGNC name peroxiredoxin 1
HGNC id 9352
Location 1p34.1      Physical location : 45.976.707 - 45.987.609
Synonym name
  • proliferation-associated gene A
  • natural killer-enhancing factor A
  • thioredoxin peroxidase 2
  • Synonym symbol(s) PAGA, PAGB, TDPX2, PAG, NKEFA, MSP23, PRX1, PRXI
    EC.number 1.11.1.15
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 11.85 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see GUCA2A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1262 - 199 - 2008 18501712
    6 - 1236 - 199 - 2008 18501712
    6 - 1042 - 199 - 2008 18501712
    6 - 1046 - 199 - 2008 18501712
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    Skin/Tegumentskin   highly
    Visualeyesclera  highly Homo sapiens
     eyeanterior segmentiris   Homo sapiens
     eyeretina    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiensFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousglia Homo sapiens
    Nervousneuron Homo sapiens
    Visualcone photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Prdx1
    Homologene
    FAMILY
  • thioredoxin peroxidase family
  • peroxiredoxin protein family
  • 2-Cys Prx subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • strong cytoplasmic labeling in the basal cells of the corneal epithelial layer and the corneoscleral limbus
  • localized mainly in the nucleus of neural cells
  • basic FUNCTION
  • playing a role in elimination of peroxides generated during metabolism
  • having a function in apoptosis signal-regulating kinase 1 (MAP3K5)-mediated signaling pathway
  • have a role in both the resistance of certain cancers to therapy and quite a different role in possibly slowing the progression of neurodegenerative
  • having a function in apoptosis signal-regulating kinase 1 (MAP3K5)-mediated signaling pathway
  • peroxidase function of PRDX1 is involved in regulating RAS-induced transformation
  • pivotal regulator of GDPD5 activity, suggesting roles for coupled thiol-redox-dependent cascades in controlling neuronal differentiation in the spinal cord
  • catalyze peroxide reduction of H(2)O(2), organic hydroperoxides and peroxynitrite
  • involved in the cellular protection against oxidative stress, the modulation of intracellular signalling cascades as well as the regulation of cell proliferation and apoptosis
  • essential for preventing respiratory syncytial virus-induced oxidative damage in a subset of nuclear intermediate filament and actin binding proteins in epithelial cells
  • PRDX1-stimulated endothelial cell proliferation, migration, and differentiation in a TLR4- and VEGF-dependent manner
  • role in regulating TGFB1-induced epithelial-to-mesenchymal transition (EMT)
  • detoxifies peroxide substrates and has been implicated in numerous biological processes, including cell growth, proliferation, differentiation, apoptosis, and redox signaling
  • may perform biological functions as a RNA-binding protein, which are distinctive from known functions of PRDX1 as a reactive oxygen species scavenger
  • novel role of PRDX1 in phagocytosis of macrophage
  • orchestrates potentially redox signaling in an H&
  • 8322;O&
    8322; dose-dependent manner through the oxidation status of its peroxidatic cysteine Cys52
  • is involved in disassembly of flagella and cilia, and suggested that the abnormal expression of the cilia-related gene including PRDX1 may affect both ciliogenesis and cancerogenesis
  • site-specific acetylation of PRDX1 may change its biological role in response to environmental changes
  • involved in the control of the pericentrosomal H2O2 level that is critical for mitotic progression
  • interaction of PRDX1 with APEX1 represents a novel anti-inflammatory function of PRDX1, whereby the association safeguards APEX1 from reducing transcription factors and activating superfluous gene expression, which otherwise could trigger cancer invasion and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text skeletal development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PSEN1 (to protects against neuronal apoptosis)
  • interacts with MAP3K5 via the thioredoxin-binding domain of MAP3K5 and this interaction is highly inducible by H2O2
  • interacts with AR and enhances its transactivation
  • binding to PTEN is essential for protecting PTEN from oxidation-induced inactivation
  • cooperates with GDPD5 to drive motor neuron differentiation, and this synergy requires PRDX1 thiol-dependent catalysis
  • regulated the expression of two E-cadherin transcriptional repressors, SNAI1, SNAI2
  • specifically coordinates MAPK14-induced signaling through regulating MAPK14 phosphatases in an H&
  • 8322;O&
    8322; dose-dependent manner
  • PRDX1, regulator of aging, is a novel PIN1 binding protein, and PIN1 is involved in regulation of PRDX1 peroxidase activity
  • APEX1 interacts with a novel partner PRDX1, a peroxidase that can also prevent oxidative damage to proteins by serving as a chaperone
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    is an important factor in esophageal squamous cancer progression and could serve as a useful prognostic marker
    tumoral     --over  
    in asbestos-related lung cancer-adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker potential use of PRDX1 as a biomarker for abdominal aortic aneurysm (AAA) evolution
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    disrupting the interaction between PRDX1 and AR may serve as a fruitful new target in the management of prostate cancer
    cancerreproductiveprostate
    novel therapeutic target for prostate carcinoma
    cancermetastases 
    regulation of EMT induction by hPrx1 may be a potential target for therapeutic strategies directed against cancer metastasis
    ANIMAL & CELL MODELS
  • Prdx1-deficient (Prdx1-/-) mice showed increased susceptibility to Mycobacterium tuberculosis