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FLASH GENE
Symbol PRCP contributors: mct/npt - updated : 29/10/2008
HGNC name prolylcarboxypeptidase (angiotensinase C)
HGNC id 9344
Location 11q14      Physical location : 82.535.409 - 82.611.557
Synonym name
  • angiotensinase C
  • lysosomal Pro-x carboxypeptidase
  • prolylcarboxypeptidase
  • Synonym symbol(s) PCP, MGC2202, HUMPCP
    EC.number 3.4.16.2
    DNA
    TYPE functioning gene
    STRUCTURE 76.15 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D11S901 - PRCP - D11S1135 - qter
    Authors Watson (97)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2161 51 496 - Wang, Mallela (2008)
    10 - 2224 - 517 - Wang, Mallela (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveesophagus   highly
     pharynx   highly
    Reproductivefemale systemplacenta  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 179 AAs of N-terminal region could play an important role in the folding and the dimerization of the polypeptides
  • serine or threonine residues repeated as the 26th residue 7 out of 9 times
  • with identical or similar amino-acids in the other positions in the repeats
  • C-terminal region of the PRCP contributes to PRCP catalytic function
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase S28 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • plasma and endothelial prekallikrein (PK) activator, cleaving C-terminal amino acids linked to proline in peptides such as angiotension II, III
  • polypeptide that folds back on itself to form a three-dimensional functional structure
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS