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FLASH GENE
Symbol PRC1 contributors: mct/pgu - updated : 14-01-2014
HGNC name protein regulator of cytokinesis 1
HGNC id 9341
Location 15q26.1      Physical location : 91.509.273 - 91.537.804
Synonym name
  • anaphase spindle elongation 1 homolog
  • protein regulating cytokinesis 1
  • Synonym symbol(s) ASE1, MGC1671, MGC3669
    DNA
    TYPE functioning gene
    STRUCTURE 28.54 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3128 - 620 - 2007 17233835
  • isoform 1
  • 14 - 3091 - 606 - 2007 17233835
  • isoform 2
  • 14 - 3011 - 566 - 2007 17233835
  • isoform 3
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinepancreas   moderately
    Lymphoid/Immunethymus   highly
    Nervousbrain   highly
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, interphase, S, G2, checkpoint, G2M
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two CDK phosphorylation motifs (phosphorylation is possibly important to mitotic suppression of bundling)
  • N-terminal region rich in alpha-helical sequence, is important for localization to the cleavage furrow and to the center of the midbody
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to yeast budding ase1p
    Homologene
    FAMILY
  • MAP65/ASE1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text nucleus during interphase, mitotic spindle during mitosis, cell midbody during cytokinesis
    basic FUNCTION
  • microtubule-associated protein required to maintain the spindle midzone
  • crucial role in midzone formation, indicating that cell cycle-dependent translocation of PRC1 by KIF4A is essential for midzone formation and cytokinesis
  • essential factor in controlling the spatiotemporal formation of the midzone in human cells
  • functional involvement of PRC1 during the meiotic prophase of male germ cells and regulatory role of SCMH1 for PRC1, which involves sex chromosomes
  • recruiting CLASP1 to the central spindle at early anaphase onset, to organize central spindle plasticity in mitosis
  • by combining structural flexibility and rigidity, tune microtubule associations to establish crosslinks that selectively "mark" antiparallel overlap in dynamic cytoskeletal networks
  • even in the absence of spindle bipolarity, PRC1 appears to be essential for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly, whereas KIF4A is required for limiting the length of anaphase microtubules
  • having a central role in the regulation of heritable gene silencing during differentiation and development
  • plays a key role in organizing the midzone complex
  • PRC1 and KIF4A, two microtubule-associated proteins required for midzone assembly, can tag microtubule plus ends
  • anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MPHOSPH1/PRC1 complex is likely to play a crucial role in bladder carcinogenesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between endogenous PRC1 and the previously uncharacterized kinesin KIF14 as well as other mitotic kinesins (MKlp1/CHO1, MKlp2, and KIF4A)
  • interaction between MPHOSPH1 and protein regulator of cytokinesis 1 (PRC1)
  • interacting with CLASP1
  • regulated by PLK1, rather than CDK1 as previously proposed, because its activity must be spatiotemporally regulated both preanaphase and postanaphase, and CDK1 activity is too binary for this purpose
  • KIF4A phosphorylation by Aurora B stimulates the maximal microtubule-dependent ATPase activity of KIF4A and promotes its interaction with PRC1
  • TRIM28 and PRC1 bound cooperatively at the promoters of differentiation-inducible genes and repressed their transcription
  • MED12 operates together with PRC1 to silence key developmental genes in pluripotency
  • cell & other
    REGULATION
    inhibited by PLK1 that negatively regulates PRC1 through phosphorylation of a single site, Thr-602, near the C-terminus of PRC1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    tumoral     --over  
    in bladder cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerurinarybladder
    inhibition of the MPHOSPH1/PRC1 expression or their interaction should be novel therapeutic targets for bladder cancers
    ANIMAL & CELL MODELS