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FLASH GENE
Symbol PRB4 contributors: mct - updated : 07-04-2022
HGNC name proline-rich protein BstNI subfamily 4
HGNC id 9340
Location 12p13.2      Physical location : 11.460.015 - 11.463.366
Synonym name
  • salivary proline-rich protein
  • parotid 'o' protein
  • basic salivary proline-rich protein 4
  • Synonym symbol(s) Po
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text including the polymorphic variants Po+/-,and glycoprotein II-1
    STRUCTURE 3.36 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 923 - 247 - 2016 26375204
    4 - 716 - 178 - 2016 26375204
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth     Homo sapiens
     salivary glandparotid  specific Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandular  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    proline-rich protein, basic, glycosylated
    HOMOLOGY
    Homologene
    FAMILY BstNI subfamily 4
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION proline-rich salivary protein
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NSD1 could bind to the promoter regions of PRB4 and activate promoter activity by reducing the binding of H3K27me2 and increasing the binding of H3K36me2 on PRB4 promoter
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential prognostic biomarkers for hypopharyngeal carcinoma treatment
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhead and neck 
    potential therapeutic target for hypopharyngeal carcinoma treatment
    ANIMAL & CELL MODELS