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FLASH GENE
Symbol PRAM1 contributors: - updated : 19-07-2006
HGNC name PML-RARA regulated adaptor molecule 1
HGNC id 30091
Location 19p13.2      Physical location : 8.554.940 - 8.567.538
Genatlas name PML-RARalpha target gene encoding an Adaptor Molecule-1
DNA
TYPE functioning gene
STRUCTURE 19.00 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  moderately
Lymphoid/Immunespleen   moderately
 thymus   highly
Reproductivefemale systemovary  moderately
cell lineage
cell lines
fluid/secretion blood predominantly
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight N-terminal proline-rich repeats
  • Several proline residues are clustered as type I or type II SH3 recognition motifs
  • group I SH2 domains as well as an SH3-like domain in the C terminus
    • HOMOLOGY
    intraspecies homolog to FYB/SLAP-130
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • expressed and regulated during normal myelopoiesis
  • playing a critical role for select integrin functions in neutrophils
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text
  • expressed and regulated during myelopoiesis
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by retinoic acid
    inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    during the induced granulocytic differentiation of promyelocytic leukemic cells and during normal human myelopoiesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS