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FLASH GENE
Symbol PQBP1 contributors: mct/npt - updated : 08-07-2010
HGNC name polyglutamine binding protein 1
HGNC id 9330
Corresponding disease
GIHS Golabi-Ito-Hall syndrome
MRX55 mental retardation, 55
RENS1 mental retardation X-linked, Renpenning syndrome 1
SHS Sutherland-Haan syndrome
Location Xp11.23      Physical location : 48.755.194 - 48.760.421
Synonym name
  • nuclear protein containing WW domain 38kDa
  • polyglutamine tract-binding protein 1
    • Synonym symbol(s) NPW38
    DNA
    TYPE functioning gene
    STRUCTURE 5.23 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   ALU
    MAPPING cloned Y linked N status provisional
    Physical map
    SLC38A5 Xp11.23 solute carrier family 38, member 5 FTSJ1 Xp11.23 FtsJ homolog 1 (E. coli) PPN Xp11.23 likely ortholog of mouse porcupine homolog (Drosophila) EBP Xp11.23-p11.22 emopamil binding protein (sterol isomerase) OATL1 Xp11.23-p11.22 ornithine aminotransferase-like 1 RBM3 Xp11.23 RNA binding motif protein 3 MRPL32P1 Xq11.23 RNA binding motif protein 3 WDR13 Xp11.23 WD repeat domain 13 WAS Xp11.23-p11.22 Wiskott-Aldrich syndrome (eczema-thrombocytopenia) SUV39H1 Xp11.23 suppressor of variegation 3-9 homolog 1 (Drosophila) LOC392465 X similar to RIKEN cDNA 2010001H14 LOC389854 X similar to Acetyl-coenzyme A acyltransferase 2 GATA1 Xp11.23 GATA binding protein 1 (globin transcription factor 1) HDAC6 Xp11.23 histone deacetylase 6 ERAS Xpter-q26 ES cell expressed Ras PCSK1N Xp11.23 proprotein convertase subtilisin/kexin type 1 inhibitor TIMM17B Xp11.23 translocase of inner mitochondrial membrane 17 homolog B (yeast) PQBP1 Xp11.3 polyglutamine binding protein 1 SLC35A2 Xp11.23-p11.22 solute carrier family 35 (UDP-galactose transporter), member A2 PIM2 Xp11.3-p11.2 pim-2 oncogene DKFZp761A052 Xp11.23 hypothetical protein DKFZp761A052 KCND1 Xp11.23 potassium voltage-gated channel, Shal-related subfamily, member 1 GRIPAP1 Xp11 GRIP1 associated protein 1 TFE3 Xp11.23-p11.22 transcription factor binding to IGHM enhancer 3 JM11 Xp11.23 JM11 protein JM4 Xp11.23 JM11 protein JM5 Xp11.23 JM5 protein T54 Xp11.23 T54 protein FLJ21687 Xp11.23 PDZ domain containing, X chromosome PLP2 Xp11.23 proteolipid protein 2 (colonic epithelium-enriched) LMO6 Xp11.23-p11.22 LIM domain only 6 SYP Xp11.23-p11.22 synaptophysin CACNA1F Xp11.23 calcium channel, voltage-dependent, alpha 1F subunit LOC347348 Xp11.23 similar to Heat shock 27 kDa protein (HSP 27) (Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDa protein) (28 kDa heat shock protein) JM1 Xp11.23 JM1 protein FOXP3 Xp11.23 forkhead box P3 PPP1R3F Xp11.23 protein phosphatase 1, regulatory (inhibitor) subunit 3F LOC286408 Xp11.23 hypothetical LOC286408 LOC389855 X similar to G antigen 7
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 1147 - 265 - Iwamoto (2000)
    7 - 1014 30.5 265 fetal brain and adult Iwamoto (2000)
    7 splicing 1093 - 265 fetal brain and adult Iwamoto (2000)
    7 splicing 1082 30.5 265 - Iwamoto (2000)
    7 splicing 1002 30 265 - Iwamoto (2000)
    - - 994 - 264 - -
    - - 972 - 257 - Iwamoto (2000)
    - - 611 - 165 - Iwamoto (2000)
    - - 797
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain   predominantly
    Reproductivemale systemprostate   
    Respiratorylung   highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, neonatal
    Text highly in fetal central nervous system and decrease after birth
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two conserved TRP (w) residues WW domain, interacting with the large subunit of RNA polymerase 2, with a critical role of the WW domain in the function of the PQBP1 protein (Tapia 2010)
  • homopolymeric glutamine repeat
  • polar amino acid rich domain
  • nuclear localization signal (NLS)
  • includes high content of unstructured regions in the C-terminal domain, in spite of the binding of U5-15kD (Takahashi 2009)
    • HOMOLOGY
    interspecies homolog to murine Pqbp1
    Homologene
    FAMILY
    CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • may be involved in neuronal proliferation and/or maturation
  • plays an important role in X-linked mental retardation (Musante 2010)
  • nuclear protein that regulates pre-mRNA splicing and transcription (Tapia 2010)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription activator
    PATHWAY
    metabolism
    signaling
    a component WBP11-PQBP1-induced nuclear inclusions are distinct from the protein aggregates that are associated with polyglutamine diseases and represent dynamic nucleoplasmic heteropolymers of WBP11 and PQBP1 (Nicolaescu 2008)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with POU3F2 (Waragai 1999)
  • pre-mRNA splicing factor WBP11, is a protein ligand of PQBP1 (Nicolaescu 2008)
  • interacts with disease proteins containing expanded polyglutamine repeats and also with RNA polymerase II and a spliceosomal protein U5-15kD(Takahashi 2009)
  • WBP11 splicing factor, is one of the functional partners of PQBP1 from a potentially large repertoire of other signaling ligands
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SHS , MRX55 , RENS1 , GIHS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    results in the formation of nuclear inclusions, reminiscent of the protein aggregates that are detected in polyglutamine diseases (Nicolaescu 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS