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FLASH GENE
Symbol PPP5C contributors: mct - updated : 21-10-2014
HGNC name protein phosphatase 5, catalytic subunit
HGNC id 9322
Location 19q13.32      Physical location : 46.850.293 - 46.894.103
Synonym name Serine/Threonine phosphatase
Synonym symbol(s) PP5, PPP5
EC.number 3.1.3.16
DNA
TYPE functioning gene
STRUCTURE 43.98 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
GIPR 19q13.3 gastric inhibitory polypeptide receptor SNRPD2 19q13.2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa FLJ20084 19q13.32 hypothetical protein FLJ20084 20D7-FC4 LOC388553 19 LOC388553 SIX5 19q13.3 sine oculis homeobox homolog 5 (Drosophila) DMPK 19q13.3 dystrophia myotonica-protein kinase DMWD 19q13.3 dystrophia myotonica-containing WD repeat motif RSHL1 19q13.3 radial spokehead-like 1 SYMPK 19q13.32 symplekin FOXA3 19q13.2-q13.4 forkhead box A3 IRF2BP1 19q13.32 interferon regulatory factor 2 binding protein 1 LOC339344 19q13.32 hypothetical protein LOC339344 NANOS2 19q13.32 nanos homolog 2 (Drosophila) NOVA2 19q13.3 neuro-oncological ventral antigen 2 LOC388554 19 similar to BC282485_1 PGLYRP 19q13.2-q13.3 peptidoglycan recognition protein LOC339346 19q13.33 similar to histidine secretory acid phosphatase LOC388555 19 similar to RPRC483 LOC126052 19q13.33 TGFB-induced factor (TALE family homeobox) pseudogene LOC147920 19q13.33 similar to VPRI645 LOC390944 19 similar to 60S ribosomal protein L12 UNQ644 19q13.33 APRG644 HIF3A 19q13.33 hypoxia inducible factor 3, alpha subunit PPP5C 19q13.3 protein phosphatase 5, catalytic subunit DKFZP564K0322 LOC390945 19 similar to paraneoplastic neuronal antigen MM2 FLJ10781 19q13.33 hypothetical protein FLJ10781 KIAA1183 19q13.33 KIAA1183 protein LOC390946 19 similar to Serine/threonine protein phosphatase 5 (PP5) (Protein phosphatase T) (PP-T) (PPT) LOC390947 19 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) CALM3 19q13.3 calmodulin 3 (phosphorylase kinase, delta) PTGIR 19q13.3 prostaglandin I2 (prostacyclin) receptor (IP) GNG8 19q13.2-q13.3 guanine nucleotide binding protein (G protein), gamma 8 MGC15476 19q13.33 thymus expressed gene 3-like PRKD2 19q13.2 thymus expressed gene 3-like STRN4 19q13.2 striatin, calmodulin binding protein 4 FKRP 19q13.33 fukutin related protein SLC1A5 19q13.3 solute carrier family 1 (neutral amino acid transporter), member 5 LOC390948 19 similar to heterogeneous nuclear ribonucleoprotein M isoform a; heterogenous nuclear ribonucleoprotein M4; N-acetylglucosamine receptor 1; M4 protein; heterogenous nuclear ribonucleoprotein M AP2S1 19q13.2-q13.3 adaptor-related protein complex 2, sigma 1 subunit GRLF1 19q13.3 glucocorticoid receptor DNA binding factor 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2232 - 499 - 2004 15155720
12 - 2166 - 477 - 2004 15155720
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Nervousbrain   highly Homo sapiens
Skin/Tegumentskin   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four tetratricopeptide motifs (TPR repeats) in the N terminus
  • a C terminal phosphatase catalytic domain
  • HOMOLOGY
    interspecies homolog to murine Ppp5c
    homolog to C.elegans Y39B6B.FF
    homolog to yeast S.cerevisiae ppt1
    Homologene
    FAMILY
  • serine/threonine protein phosphatase family
  • phosphoprotein phosphatase family of a serine/threonine phosphatase
  • CATEGORY enzyme , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text nuclear predominantly
    basic FUNCTION
  • serine/threorine phosphatase 5, involved in regulation of RNA biogenesis and/or mitosis
  • involved in wide-ranging cellular processes, including DNA damage repair, cell growth and differentiation, cell cycle arrest, and cellular heat shock response
  • functions in signalling pathways that control cellular responses to stress, glucocorticoids and DNA damage
  • is a physiological regulator of RAF1 signalling pathways
  • plays likely a crucial role in ATR-mediated repair of UV-induced DNA damage
  • helps suppress apoptosis in beta cells by a mechanism that involves regulation of JNK phosphorylation
  • CELLULAR PROCESS cell cycle, division, mitosis
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAP3K5
  • CDC16, CDC27, hCRY2, HSP90-GR complex
  • mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-&
  • 947; (PPARG)
  • is a novel target of S100 proteins (
  • binding of S100A1, S100A2, S100A6 and S100B, which interact with the TPR domain of PPP5C, leading to a full activation of the enzyme (
  • MAP3K5 similar to HSP90AA1, associates with PPP5C through its TPR domains, and thereby, PPP5C dephosphorylates the essential pThr-845 in the kinase domain of MAP3K5 (
  • S100A1, S100A2, S100A6, and S100B proteins specifically interact with PPP5C-tetratricopeptide repeat (TPR) domain
  • modulates SMAD3 function in the TGFB pathway
  • KLHDC10 bound to the phosphatase domain of PPP5C and suppressed its phosphatase activity
  • caveolin-1 is a novel physiological activator of PPP5C
  • HSPA8 recruits PPP5C and activates its phosphatase activity which suggests dual roles for PPP5C that might link chaperone systems with signaling pathways in cancer and development
  • differential responsiveness of PPP5C-MAPK1 and PPP5C-MAPK2 interactions to select oncogenic RAS variants (
  • cell & other
    REGULATION
    activated by the S100 proteins increased the dephosphorylation of MAPT, known as a physiological substrate of PPP5C (
    HSP90AA1 that activates PPP5C by disrupting TPR-phosphatase domain interactions, permitting substrate access to the constitutively active phosphatase domain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    might be an effective therapeutic target in Alzheimer disease and other neurodegenerative disorders in which oxidative stress is implicated (PMID: 19686245)
    ANIMAL & CELL MODELS
  • Pp5 deficiency in mice is associated with reduced weight gain, lower fasting glycaemia