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FLASH GENE
Symbol PPP5C contributors: mct - updated : 21-10-2014
HGNC name protein phosphatase 5, catalytic subunit
HGNC id 9322
Location 19q13.32      Physical location : 46.850.293 - 46.894.103
Synonym name Serine/Threonine phosphatase
Synonym symbol(s) PP5, PPP5
EC.number 3.1.3.16
DNA
TYPE functioning gene
STRUCTURE 43.98 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2232 - 499 - 2004 15155720
12 - 2166 - 477 - 2004 15155720
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Nervousbrain   highly Homo sapiens
Skin/Tegumentskin   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four tetratricopeptide motifs (TPR repeats) in the N terminus
  • a C terminal phosphatase catalytic domain
  • HOMOLOGY
    interspecies homolog to murine Ppp5c
    homolog to C.elegans Y39B6B.FF
    homolog to yeast S.cerevisiae ppt1
    Homologene
    FAMILY
  • serine/threonine protein phosphatase family
  • phosphoprotein phosphatase family of a serine/threonine phosphatase
  • CATEGORY enzyme , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text nuclear predominantly
    basic FUNCTION
  • serine/threorine phosphatase 5, involved in regulation of RNA biogenesis and/or mitosis
  • involved in wide-ranging cellular processes, including DNA damage repair, cell growth and differentiation, cell cycle arrest, and cellular heat shock response
  • functions in signalling pathways that control cellular responses to stress, glucocorticoids and DNA damage
  • is a physiological regulator of RAF1 signalling pathways
  • plays likely a crucial role in ATR-mediated repair of UV-induced DNA damage
  • helps suppress apoptosis in beta cells by a mechanism that involves regulation of JNK phosphorylation
  • CELLULAR PROCESS cell cycle, division, mitosis
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAP3K5
  • CDC16, CDC27, hCRY2, HSP90-GR complex
  • mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-&
  • 947; (PPARG)
  • is a novel target of S100 proteins (
  • binding of S100A1, S100A2, S100A6 and S100B, which interact with the TPR domain of PPP5C, leading to a full activation of the enzyme (
  • MAP3K5 similar to HSP90AA1, associates with PPP5C through its TPR domains, and thereby, PPP5C dephosphorylates the essential pThr-845 in the kinase domain of MAP3K5 (
  • S100A1, S100A2, S100A6, and S100B proteins specifically interact with PPP5C-tetratricopeptide repeat (TPR) domain
  • modulates SMAD3 function in the TGFB pathway
  • KLHDC10 bound to the phosphatase domain of PPP5C and suppressed its phosphatase activity
  • caveolin-1 is a novel physiological activator of PPP5C
  • HSPA8 recruits PPP5C and activates its phosphatase activity which suggests dual roles for PPP5C that might link chaperone systems with signaling pathways in cancer and development
  • differential responsiveness of PPP5C-MAPK1 and PPP5C-MAPK2 interactions to select oncogenic RAS variants (
  • cell & other
    REGULATION
    activated by the S100 proteins increased the dephosphorylation of MAPT, known as a physiological substrate of PPP5C (
    HSP90AA1 that activates PPP5C by disrupting TPR-phosphatase domain interactions, permitting substrate access to the constitutively active phosphatase domain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    might be an effective therapeutic target in Alzheimer disease and other neurodegenerative disorders in which oxidative stress is implicated (PMID: 19686245)
    ANIMAL & CELL MODELS
  • Pp5 deficiency in mice is associated with reduced weight gain, lower fasting glycaemia