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FLASH GENE
Symbol PPP3CC contributors: - updated : 22-12-2005
HGNC name protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)
HGNC id 9316
Location 8p21.2      Physical location : 22.298.595 - 22.398.635
Synonym symbol(s) CALNG, CALNA3
EC.number 3.1.3.16
DNA
TYPE functioning gene
STRUCTURE 84.00 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
text existence of an alternatively spliced variant (Muramatsu)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systembreastmammary gland  
 male systemtestis  specific
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Skeletonosteoblast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a catalytic domain
  • the binding domains for calcineurin B subunit and for calmodulin
  • the C terminal autoinhibitory peptide (AID)
  • HOMOLOGY
    interspecies ortholog to murine Ppp3cc
    homolog to C.elegans Co2f4.2
    Homologene
    FAMILY
  • PPP family of phosphatases
  • PP-2b subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • calmodulin dependent serine/threonine phosphatase 2B, catalytic subunit
  • playing a role in the calmodulin activation of calcineurin
  • regulating bone formation through an effect on osteoblast differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    calcineurin signaling pathway
    a component
  • composed of the component being the catalytic subunit and the b component conferring calcium sensibility
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein RCAN1, RCAN2
    cell & other
    REGULATION
    activated by calmodulin
    Other calcium dependent
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia (SCZD6)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS