Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PPP3CC contributors: - updated : 22-12-2005
HGNC name protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)
HGNC id 9316
Location 8p21.2      Physical location : 22.298.595 - 22.398.635
Synonym symbol(s) CALNG, CALNA3
EC.number 3.1.3.16
DNA
TYPE functioning gene
STRUCTURE 84.00 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
GFRA2 8p22-p21 GDNF family receptor alpha 2 DOK2 8p21.2 docking protein 2, 56kDa XPO7 8p21 exportin 7 NPM2 8p21.3 nucleophosmin/nucleoplasmin, 2 FGF17 8p21 fibroblast growth factor 17 EPB49 8p21.1 erythrocyte membrane protein band 4.9 (dematin) RAI16 8p21.2 retinoic acid induced 16 FLJ22494 8p21.3 hypothetical protein FLJ22494 HR 8p22-p21 hairless homolog (mouse) FLJ22246 8p21.3 hypothetical protein FLJ22246 LGI3 8p21.2 leucine-rich repeat LGI family, member 3 SFTPC 8p21.2 surfactant, pulmonary-associated protein C BMP1 8p21.2 bone morphogenetic protein 1 PHYHIP 8p21.2 phytanoyl-CoA hydroxylase interacting protein POLR3D 8q21 polymerase (RNA) III (DNA directed) polypeptide D, 44kDa PIWIL2 8p21.2 piwi-like 2 (Drosophila) SLC39A14 8p21.2 solute carrier family 39 (zinc transporter), member 14 PPP3CC 8p21.2 protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma) LOC389639 8 LOC389639 SCAM-1 8p21.2 vinexin beta (SH3-containing adaptor molecule-1) PDLIM2 8p21.2 PDZ and LIM domain 2 (mystique) DBC-1 8p22 p30 DBC protein BIN3 8p21.2 bridging integrator 3 FLJ14107 8p21.2 hypothetical protein FLJ14107 EGR3 8p23-p21 early growth response 3 MGC22776 8p21.2 hypothetical protein MGC22776 RHOBTB2 8p21.2 Rho-related BTB domain containing 2 TNFRSF10B 8p21 tumor necrosis factor receptor superfamily, member 10b LOC389640 8 LOC389640 TNFRSF10C 8p21 tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain TNFRSF10D 8p21 tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain TNFRSF10A 8p21 tumor necrosis factor receptor superfamily, member 10a LOC389641 8 hypothetical gene supported by AK124295 MGC29816 8p21.2 hypothetical protein MGC29816 LOC203069 8p21.2 hypothetical protein LOC203069 LOXL2 8p21.3-p21.2 lysyl oxidase-like 2
RNA
TRANSCRIPTS type messenger
text existence of an alternatively spliced variant (Muramatsu)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systembreastmammary gland  
 male systemtestis  specific
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Skeletonosteoblast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a catalytic domain
  • the binding domains for calcineurin B subunit and for calmodulin
  • the C terminal autoinhibitory peptide (AID)
  • HOMOLOGY
    interspecies ortholog to murine Ppp3cc
    homolog to C.elegans Co2f4.2
    Homologene
    FAMILY
  • PPP family of phosphatases
  • PP-2b subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • calmodulin dependent serine/threonine phosphatase 2B, catalytic subunit
  • playing a role in the calmodulin activation of calcineurin
  • regulating bone formation through an effect on osteoblast differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    calcineurin signaling pathway
    a component
  • composed of the component being the catalytic subunit and the b component conferring calcium sensibility
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein RCAN1, RCAN2
    cell & other
    REGULATION
    activated by calmodulin
    Other calcium dependent
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia (SCZD6)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS