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FLASH GENE
Symbol PPP3CB contributors: mct - updated : 27-08-2012
HGNC name protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)
HGNC id 9315
Location 10q22.3      Physical location : 75.196.563 - 75.255.782
Synonym name
  • CAM-PRP catalytic subunit
  • calcineurin A beta
  • calcineurin A2
  • calmodulin-dependent calcineurin A subunit beta isoform
  • Synonym symbol(s) CALNB, CALNA2, CNA2, PP2Bbeta, CnAbeta
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 59.22 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • 2.3-kb promoter is specifically activated by hypertrophic stimuli through a positive feedback mechanism involving NFATC1 and GATA4 transcription factors, suggesting transcriptional induction of PPP3CB expression as an additional means of regulating calcineurin activity in the heart
  • MAPPING cloned Y linked N status confirmed
    Physical map
    FLJ39116 10q22.2-q22.3 oncoprotein induced transcript 3 PLA2G13 10q22.3 phospholipase A2, group XIII LOC148854 10q22.3 similar to 60S ribosomal protein L17 (L23) P4HA1 10q22.3 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I NUDT13 10q22.3 nudix (nucleoside diphosphate linked moiety X)-type motif 13 HSGT1 10q22.3 nudix (nucleoside diphosphate linked moiety X)-type motif 13 DNAJC9 10q22.3 DnaJ (Hsp40) homolog, subfamily C, member 9 MRPS16 10q22.1 mitochondrial ribosomal protein S16 LOC118491 10q22.3 tetratricopeptide repeat-containing protein ANXA7 10q21.1-q21.2 annexin A7 ZMYND17 10q22.3 zinc finger, MYND domain containing 17 PPP3CB 10q22.3 protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta) C10orf29 MYOZ1 10q22.1 myozenin 1 SYNPO2L 10q22.3 synaptopodin 2-like LOC118704 10q22.3 similar to ARF GTPase-activating protein LOC389978 10 similar to Ribosome biogenesis protein BMS1 homolog GLUDP3 10q22.1 glutamate dehydrogenase pseudogene 3 SEC24C 10q22.3 SEC24 related gene family, member C (S. cerevisiae) FUT11 10q22.3 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) LOC118487 10q22.3 similar to RIKEN cDNA 1110001O19 LOC196752 10q22.3 similar to CG32542-PA KIAA0913 10q22.3 KIAA0913 protein NDST2 10q22 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 CAMK2G 10q22.3 calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma PLAU 10q23.3-q24.3 plasminogen activator, urokinase
    RNA
    TRANSCRIPTS type messenger
    text at least two isoenzymes resulting from alternative splicing (Guerini)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 splicing 3164 59 524 - 1999 9920765
    14 splicing 3165 - 525 - 1999 9920765
    13 - 3137 - 515 - 1999 9920765
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    Skeletonosteoblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a catalytic domain
  • the binding domains for calcineurin B subunit and for calmodulin
  • a proline-rich sequence involved in substrate recognition
  • the C terminal autoinhibitory peptide (AID)
  • HOMOLOGY
    interspecies ortholog to murine Ppp3cb
    homolog to C.elegans Co2f4.2
    Homologene
    FAMILY
  • PPP family of phosphatases
  • PP-2b subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • calmodulin dependent serine/threonine phosphatase 2B, catalytic subunit, involved in osteoclast regulation
  • regulating activity of transcription factors involved in signal transduction
  • playing a role in the calmodulin activation of calcineurin
  • may be playing an important role for Ca(++)-dependent processes in mitochondria
  • regulating bone formation through an effect on osteoblast differentiation
  • in addition to its role in mediating TCR signals essential for T cell activation, is also required for the homeostatic survival of naive T cells
  • important for the production and maintenance of T(reg) cells and to ensure mature T-cell quiescence
  • in skeletal muscle, is necessary for myoblast proliferation and stimulates regeneration, reducing fibrosis and accelerating the resolution of inflammation
  • having a unique mode of action that improves cardiac function after myocardial infarction, activating different cardioprotective pathways without inducing maladaptive hypertrophy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text cell cycle contRol
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • composed of the "a" component being the catalytic subunit and the "b"component confering calcium sensibility
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • Mn2+
  • protein
  • RCAN1, RCAN2, calmodulin
  • interacting with tubulin and HSP60
  • enhances the spontaneous survival of naive T cells by maintaining high levels of BCL2, a critical homeostatic survival factor for naive T cells
  • PPP3CA and PPP3CB binding to EIF2AK3 enhances inhibition of protein translation to allow the cell time to recover
  • cell & other
    REGULATION
    activated by calmodulin
    Other calcium dependent
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    results in defective T cell proliferation and IL2 production in response to TCR stimulation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Cnab(-/-) mice exhibit defective thymocyte maturation, splenomegaly and hepatomegaly