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FLASH GENE
Symbol PPP2R5E contributors: mct - updated : 07-04-2016
HGNC name protein phosphatase 2, regulatory subunit B (B56), epsilon isoform
HGNC id 9313
Location 14q23.2      Physical location : 63.841.354 - 64.010.079
Synonym name
  • PP2A, B subunit, B56 epsilon
  • protein phosphatase 2, regulatory subunit B (B56), epsilon isoform
  • serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, epsilon
  • Synonym symbol(s) B56E
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 170.88 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    text two isoforms of the epsilon Mrna (Mc Cright)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 4120 - 467 - 1996 8703017
    14 - 4108 - 462 - 1996 8703017
    14 - 4123 - 467 - 1996 8703017
    13 - 3445 - 391 - 1996 8703017
    13 - 3490 - 391 - 1996 8703017
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Ppp2r5e
    homolog to C.elegans w08g11.4
    intraspecies homolog to PPP2REA,PPP2R5B,PPP2R5C,PPP2R5D
    Homologene
    FAMILY phosphatase 2a regulatory subunit b family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • modulating substrate selectivity and catalytic activity
  • directing the localization of the catalytic enzyme to a particular subcellular compartment
  • regulatory subunit of protein phosphatase 2 a consisting of a common heterodimeric core enzyme,composed of a 36kDa catalytic subunit (subunit c) and a 65kDa constant regulatory subunit (pr65 or subunit a), and associating with a variety of regulatory subunits (including three families of subunits b)
  • is involved in tumorigenesis and plays important roles in regulating apoptosis
  • KIF4A and PPP2R5C and PPP2R5E therefore create a spatially restricted negative feedback loop counteracting AURKB in anaphase
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS locomotion
    text muscle contraction
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • substrate of caspase-3, and is an essential regulator of apoptosis
  • is responsible for the dephosphorylation of H2AFX
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    is a common event in acute myeloid leukemia that affects the oncogenic potential of leukemic cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS