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FLASH GENE
Symbol PPP2R5C contributors: mct - updated : 06-04-2016
HGNC name protein phosphatase 2, regulatory subunit B (B56), gamma isoform
HGNC id 9311
Location 14q32.31      Physical location : 102.228.134 - 102.394.326
Synonym name
  • PP2A B subunit isoform B56-gamma
  • PP2A B subunit isoform PR61-gamma
  • PP2A B subunit isoform R5-gamma
  • Synonym symbol(s) B56G, PR61G
    DNA
    TYPE functioning gene
    STRUCTURE 167.42 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    C14orf68 14 chromosome 14 open reading frame 68 WARS 14q32.31 tryptophanyl-tRNA synthetase NDUFB3P4 14q NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 4 LOC388013 14 hypothetical gene supported by BX248767 MGC4645 14q32.32 hypothetical protein MGC4645 KIAA1446 14q32.32 brain-enriched guanylate kinase-associated protein LOC388014 14 LOC388014 DLK1 14q32 delta-like 1 homolog (Drosophila) MEG3 14q32 maternally expressed 3 LOC388015 14 similar to RTl1 LOC388016 14 LOC388016 LOC388017 14 LOC388017 LOC145197 14q32.32 hypothetical LOC145197 DIO3OS 14q32.33 deiodinase, iodothyronine, type III opposite strand DIO3 14q32 deiodinase, iodothyronine, type III LOC122423 14q32.33 similar to hypothetical protein ZC477.8 - Caenorhabditis elegans LOC388018 14 LOC388018 RPL26P4 14q32.34 ribosomal protein L26 pseudogene 3 C14orf72 14q32.33 chromosome 14 open reading frame 72 PPP2R5C 14q32.2 protein phosphatase 2, regulatory subunit B (B56), gamma isoform NPM1P20 14q32.33 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 20 DNCH1 14q32-qter dynein, cytoplasmic, heavy polypeptide 1 HSPCA 14q32.33 heat shock 90kDa protein 1, alpha WDR20 14q32.33 WD repeat domain 20 RAGE 14q32 renal tumor antigen C14orf131 14q32.33 chromosome 14 open reading frame 131 CINP 14q32.33 cyclin-dependent kinase 2-interacting protein KIAA0329 14q32-.11 cyclin-dependent kinase 2-interacting protein ANKRD9 14q32.33 ankyrin repeat domain 9 LOC283604 14q32.33 hypothetical LOC283604 RCOR 14q32.32 REST corepressor RPL23AP11 14 ribosomal protein L23a pseudogene 11 TRAF3 14q32.3 TNF receptor-associated factor 3 AMN 14q32.3 amnionless homolog (mouse) CDC42BPB 14q32.3 CDC42 binding protein kinase beta (DMPK-like) C14orf73 14 chromosome 14 open reading frame 73 TNFAIP2 14q32 tumor necrosis factor, alpha-induced protein 2 RPL21P12 14q32.33 ribosomal protein L21 pseudogene 12
    RNA
    TRANSCRIPTS type messenger
    text the three variants are identical until exon 12 (Muneer)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 splicing 1623 - 449 nuclear 2002 11863364
  • gamma-1 or V3
  • not phosphorylated on serine
  • 13 splicing 4328 - 485 - 2002 11863364
  • gamma-2 or V2
  • ATM directly phosphorylates and specifically regulates isoform gamma2 and gamma3, after DNA damage
  • - splicing 4445 61 524 . nuclear . heart, skeletal, brain-highly . pancreas, kidney, lung, placenta lowly, liver very lowly 2002 11863364
  • B prime alpha 1 and gamma 3
  • phosphorylated on serines
  • ATM directly phosphorylates and specifically regulates isoform gamma2 and gamma3, after DNA damage
  • - - 1460 - 384 - 2002 11863364
    16 - 4494 - 555 - 2002 11863364
    15 - 4449 - 540 - 2002 11863364
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Homo sapiens
    Lymphoid/Immunelymph node   highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight HEAT (Huntington-elongation-A subunit-TOR) repeat motifs, and HEAT repeat 1 is required for PPP2R5C tumor-suppressive function
  • secondary structure
  • 18 alpha-helices that are organized into eight HEAT (Huntington-elongation-A subunit-TOR) repeat motifs
  • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies ortholog to murine Ppp2r5c
    homolog to C.elegans C13G3.3A
    intraspecies homolog to PPP2R5A
    homolog to PPP2R5B
    homolog to PPP2R5D
    homolog to PPP2R5E
    Homologene
    FAMILY phosphatase 2a regulatory subunit b family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,centromere
    basic FUNCTION
  • modulating substrate selectivity and catalytic activity
  • directing the localization of the catalytic enzyme to a particular subcellular compartment
  • regulatory subunit of protein phosphatase 2A consisting of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit c) and a 65 kDa constant regulatory subunit (p65 or subunit a), and associating with a variety of regulatory subunits (including three families of subunits b...)
  • important role in tumorigenesis
  • its activity is required for efficient cardiomyocyte maturation and survival
  • is a negative regulator of NFKB1 in TCR signaling
  • KIF4A and PPP2R5C and PPP2R5E therefore create a spatially restricted negative feedback loop counteracting AURKB in anaphase
  • regulatory subunit of PP2A, and is a novel modulator of liver metabolism in postprandial physiology
  • hepatic PPP2R5C represents an important factor in the functional wiring of energy metabolism and the maintenance of a metabolically healthy state
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text muscle contraction
    PATHWAY
    metabolism
    signaling
    a component
  • common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits (B regulatory subunit might modulate substrate selectivity and catalytic activity)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • important link between ATM activity and the tumor-suppressive function of PPP2R5C
  • PPP2R5C expression is regulated by NRL during retinogenesis through direct binding to the promoter region of PPP2R5C
  • NRL activated rhodopsin and PPP2R5C transcription by recruiting KAT5 to promote histone H3/H4 acetylation
  • in addition to dephosphorylation of TP53, PPP2R5C also inhibits cell proliferation and transformation by a second, as yet unknown, TP53-independent mechanism
  • can dephosphorylate the T799 AURKB site on KIF4A and thereby counteract the AURKB- and microtubule-stimulated ATPase activity of KIF4A
  • cell & other
    REGULATION
    Other regulated by the transcription factor neural retina leucine-zipper (NRL) through enhancement of its transcriptional activity on the PPP2R5C promoter
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in isolated hepatocytes leads to increased glucose uptake and increased de novo lipogenesis
    constitutional     --over  
    in human diabetic patients, and correlate with obesity and insulin resistance in these subjects
    constitutional germinal mutation      
    cause human overgrowth
    constitutional        
    enhanced NFKB1 activity, resulting in increased NFKB1 target gene expression including the T cell cytokine IL2 and T cell proliferation was increased
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS