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FLASH GENE
Symbol PPP2R5B contributors: mct - updated : 06-04-2016
HGNC name protein phosphatase 2, regulatory subunit B (B56), beta isoform
HGNC id 9310
Location 11q13.1      Physical location : 64.692.142 - 64.701.948
Synonym name
  • serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, beta isoform
  • PP2A B subunit isoform B56-beta
  • PP2A B subunit isoform PR61-beta
    • Synonym symbol(s) FLJ35411, B56B, PR61B
    DNA
    TYPE functioning gene
    STRUCTURE 16.93 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure CAG repeat
    MAPPING cloned Y linked N status confirmed
    Map cen - PYGM PYGM - SF1 - PPP2R5B - FAU - CAPN1 - D11S449 - qter
    Authors Forbes (97)
    Physical map
    SLC22A11 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 11 SLC22A12 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 12 NRXN2 11q13.2 neurexin 2 RASGRP2 11q13 RAS guanyl releasing protein 2 (calcium and DAG-regulated) PYGM 11q13.2 phosphorylase, glycogen; muscle (McArdle syndrome, glycogen storage disease type V) SF1 11q13.2 splicing factor 1 MAP4K2 11q13 mitogen-activated protein kinase kinase kinase kinase 2 MEN1 11q13.2 multiple endocrine neoplasia I HSMDPKIN 11q13 multiple endocrine neoplasia I EHD1 11q13 EH-domain containing 1 KIAA0404 11q13.3-q13.5 EH-domain containing 1 PPP2R5B 11q13 protein phosphatase 2, regulatory subunit B (B56), beta isoform GPHA2 11q13.1 glycoprotein hormone alpha 2 LOC283129 11q13.1 hypothetical protein LOC283129 LOC116071 11q13.1 hypothetical protein BC012330 SNX15 11q12 sorting nexin 15 ARL2 11q13 ADP-ribosylation factor-like 2 LOC390210 11 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) HSU79266 11q13.1 protein predicted by clone 23627 NAALADL1 11q12 N-acetylated alpha-linked acidic dipeptidase-like 1 LOC256676 11q13.1 hypothetical LOC256676 CDCA5 11q12.1 cell division cycle associated 5 ZFPL1 11q13 zinc finger protein-like 1 C11orf2 11q13 chromosome 11 open reading frame2 TM7SF2 11q13 transmembrane 7 superfamily member 2 C11orf5 11q13 chromosome 11 open reading frame 5 FAU 11q12-q13.1 Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30 MRPL49 11q13 mitochondrial ribosomal protein L49 HRD1 11q13 HRD1 protein LOC387778 11 similar to p33 ringo LOC387779 11 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) CAPN1 11q13 calpain 1, (mu/I) large subunit
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 splicing 2766 57.4 497 - 2015 23135275
  • beta 1
  • phosphorylated on serine residues
    • - splicing - - - - 2015 23135275
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     salivary gland   highly
    Endocrinethyroid   highly
    Nervousbrain   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to C.elegans W08G11.4
    intraspecies homolog to PPP2R5A
    homolog to PPP2R5C
    homolog to PPP2R5D
    homolog to PPP2R5E
    Homologene
    FAMILY phosphatase 2a regulatory subunit b family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • modulating substrate selectivity and catalytic activity
  • directing the localization of the catalytic enzyme to a particular subcellular compartment
  • regulatory subunit of protein phosphatase 2a consisting of a common heterodimeric coreenzyme,composed of a 36 kDa catalytic subunit (subunit c) and a 65 kDa constant regulatory subunit (pr65 or subunit a),and associating with a variety of regulatory subunits (including three families of subunits b...)
    • CELLULAR PROCESS cell cycle, division
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text muscle contraction
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • phosphorylated PIM1 binds PIN1 allowing the interaction of PPP2R5B, and dephosphorylation of PIM1 then allows for ubiquitinylation and protein degradation of PIM1
  • CLK2 phosphorylates PPP2R5B, which is a critical regulatory step in the assembly of the PP2A holoenzyme complex on AKT1 leading to dephosphorylation of both S473 and T308 AKT1 sites
    • cell & other
    REGULATION
    induced by retinoic acid in neuroblastoma cell lines
    Phosphorylated by CLK2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    cause human overgrowth
    Susceptibility
    Variant & Polymorphism
    Candidate gene excluded as a candidate gene for MEN1
    Marker
    Therapy target
    ANIMAL & CELL MODELS