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FLASH GENE
Symbol PPP2R5B contributors: mct - updated : 06-04-2016
HGNC name protein phosphatase 2, regulatory subunit B (B56), beta isoform
HGNC id 9310
Location 11q13.1      Physical location : 64.692.142 - 64.701.948
Synonym name
  • serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, beta isoform
  • PP2A B subunit isoform B56-beta
  • PP2A B subunit isoform PR61-beta
    • Synonym symbol(s) FLJ35411, B56B, PR61B
    DNA
    TYPE functioning gene
    STRUCTURE 16.93 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure CAG repeat
    MAPPING cloned Y linked N status confirmed
    Map cen - PYGM PYGM - SF1 - PPP2R5B - FAU - CAPN1 - D11S449 - qter
    Authors Forbes (97)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 splicing 2766 57.4 497 - 2015 23135275
  • beta 1
  • phosphorylated on serine residues
    • - splicing - - - - 2015 23135275
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     salivary gland   highly
    Endocrinethyroid   highly
    Nervousbrain   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to C.elegans W08G11.4
    intraspecies homolog to PPP2R5A
    homolog to PPP2R5C
    homolog to PPP2R5D
    homolog to PPP2R5E
    Homologene
    FAMILY phosphatase 2a regulatory subunit b family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • modulating substrate selectivity and catalytic activity
  • directing the localization of the catalytic enzyme to a particular subcellular compartment
  • regulatory subunit of protein phosphatase 2a consisting of a common heterodimeric coreenzyme,composed of a 36 kDa catalytic subunit (subunit c) and a 65 kDa constant regulatory subunit (pr65 or subunit a),and associating with a variety of regulatory subunits (including three families of subunits b...)
    • CELLULAR PROCESS cell cycle, division
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text muscle contraction
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • phosphorylated PIM1 binds PIN1 allowing the interaction of PPP2R5B, and dephosphorylation of PIM1 then allows for ubiquitinylation and protein degradation of PIM1
  • CLK2 phosphorylates PPP2R5B, which is a critical regulatory step in the assembly of the PP2A holoenzyme complex on AKT1 leading to dephosphorylation of both S473 and T308 AKT1 sites
    • cell & other
    REGULATION
    induced by retinoic acid in neuroblastoma cell lines
    Phosphorylated by CLK2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    cause human overgrowth
    Susceptibility
    Variant & Polymorphism
    Candidate gene excluded as a candidate gene for MEN1
    Marker
    Therapy target
    ANIMAL & CELL MODELS