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FLASH GENE
Symbol PPP2R5A contributors: mct - updated : 07-04-2016
HGNC name protein phosphatase 2, regulatory subunit B (B56), alpha isoform
HGNC id 9309
Location 1q41      Physical location : 212.458.878 - 212.535.204
Synonym symbol(s) B56A, PR61A
EC.number 3.1.3.16
DNA
TYPE functioning gene
STRUCTURE 76.00 kb     13 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivemouthtongue  highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
interspecies homolog to C.elegans w08g11.4
intraspecies homolog to PPP2R5B,PPP2R5C,PPP2R5D,PPP2R5E
Homologene
FAMILY phosphatase 2A regulatory subunit b family
CATEGORY enzyme , regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • modulating substrate selectivity and catalytic activity
  • directing the localization of the catalytic enzyme to a particular compartment
  • the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component regulatory subunit b of protein phosphatase 2 A consisting of a common heterodimeric core enzyme, composed of a 36kDa catalytic subunit (subunit c) and a 65kDa constant regulatory subunit (p65 or subunit a), and associating with a variety of regulatory subunits (including three families of subunits b)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS