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FLASH GENE
Symbol PPP2R5A contributors: mct - updated : 07-04-2016
HGNC name protein phosphatase 2, regulatory subunit B (B56), alpha isoform
HGNC id 9309
Location 1q41      Physical location : 212.458.878 - 212.535.204
Synonym symbol(s) B56A, PR61A
EC.number 3.1.3.16
DNA
TYPE functioning gene
STRUCTURE 76.00 kb     13 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
KCNH1 1q32-q41 potassium voltage-gated channel, subfamily H (eag-related), member 1 LOC388733 1 similar to 40S ribosomal protein S25 LOC388734 1 similar to Px19-like protein (25 kDa protein of relevant evolutionary and lymphoid interest) (PRELI) (CGI-106) (SBBI12) FLJ10876 1q32.3 hypothetical protein FLJ10876 TRAF5 1q32 TNF receptor-associated factor 5 MGC14801 1q32.3 hypothetical protein MGC14801 LOC391160 1 similar to ARP2/3 complex 21 kDa subunit (p21-ARC) (Actin-related protein 2/3 complex subunit 3) C1orf36 1q32.3 chromosome 1 open reading frame 36 SLC30A1 1q32-q41 solute carrier family 30 (zinc transporter), member 1 LOC127184 1q32.3 similar to Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) NEK2 1q32.2-q41 NIMA (never in mitosis gene a)-related kinase 2 KIAA0205 1p36.13-q42.3 NIMA (never in mitosis gene a)-related kinase 2 DKFZP434B168 1p36.13-q42.3 DKFZP434B168 protein RAMP 1q32.1-q32.2 DKFZP434B168 protein PPP2R5A 1q41 protein phosphatase 2, regulatory subunit B (B56), alpha isoform FLJ10874 1q32.3 hypothetical protein FLJ10874 SPUF 1q32.3 secreted protein of unknown function ATF3 1q32.3 activating transcription factor 3 FLJ32796 1q32.3 hypothetical protein FLJ32796 LOC388735 1 LOC388735 SNFT 1q32.3 Jun dimerization protein p21SNFT DC8 1q41 DKFZP566O1646 protein LOC388736 1 similar to ribosomal protein S5; 40S ribosomal protein S5 LOC149643 1q32.3 hypothetical LOC149643 FLVCR 1q32.1-q32.2 hypothetical LOC149643 FLJ12505 1q32.3 hypothetical protein FLJ12505 LOC90806 1q32.3 similar to RIKEN cDNA 2610307I21 RPS6KC1 1q41 ribosomal protein S6 kinase, 52kDa, polypeptide 1 LOC391161 1 similar to ribosomal protein L31 PROX1 1q32.2-q32.3 prospero-related homeobox 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivemouthtongue  highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
interspecies homolog to C.elegans w08g11.4
intraspecies homolog to PPP2R5B,PPP2R5C,PPP2R5D,PPP2R5E
Homologene
FAMILY phosphatase 2A regulatory subunit b family
CATEGORY enzyme , regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • modulating substrate selectivity and catalytic activity
  • directing the localization of the catalytic enzyme to a particular compartment
  • the b regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component regulatory subunit b of protein phosphatase 2 A consisting of a common heterodimeric core enzyme, composed of a 36kDa catalytic subunit (subunit c) and a 65kDa constant regulatory subunit (p65 or subunit a), and associating with a variety of regulatory subunits (including three families of subunits b)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS