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FLASH GENE
Symbol PPP2R3A contributors: npt/ - updated : 16-01-2006
HGNC name protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha
HGNC id 9307
Location 3q22.2-q      Physical location : 135.684.514 - 135.866.752
Synonym name
  • protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), beta isoform
  • PP2A, subunit B, PR72/PR130 isoforms
  • PP2A, subunit B, R3 isoform
  • Synonym symbol(s) PPP2R3, PR130, PR72
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 182.17 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    H41 3q22.1 hypothetical protein H41 TOPBP1 3q22.1 topoisomerase (DNA) II binding protein LOC391579 3 similar to RIKEN cDNA 1300017J02 TF 3q21 transferrin PRO2086 3q22.1 PRO2086 protein APMCF1 3q22.1 PRO2086 protein RAB6B 3q22.2 RAB6B, member RAS oncogene family FLJ22173 3q22.1 hypothetical protein FLJ22173 SLCO2A1 3q21 solute carrier organic anion transporter family, member 2A1 RYK 3q22 RYK receptor-like tyrosine kinase AMOTL2 3q21-q22 angiomotin like 2 DKFZP566D193 3q22.1 DKFZP566D193 protein FLJ13386 3q22.1 hypothetical protein FLJ13386 FLJ33207 3q22.1 hypothetical protein FLJ33207 EPHB1 3q21-q23 EphB1 LOC391580 3 similar to Succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial precursor (Ip) (Iron-sulfur subunit of complex II) PPP2R3A 3q22.2-q protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha FLJ10546 3q22.2 hypothetical protein FLJ10546 LOC391581 3 similar to ribosomal protein L31 PCCB 3q21-q22 propionyl Coenzyme A carboxylase, beta polypeptide STAG1 3q22-q24 stromal antigen 1 MGC3295 3q22.3 hypothetical protein MGC3295 NCK1 3q21 NCK adaptor protein 1 MGC34923 3q22.3 hypothetical protein MGC34923 NPM1P17 3q22.3 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 17 SOX14 3q23 SRY (sex determining region Y)-box 14 LOC344829 3q22.3 similar to Heat shock cognate 71 kDa protein CLDN18 3q22.3 claudin 18 FLJ32844 3q22.3 hypothetical protein FLJ32844 alpha4GnT 3p14.3 hypothetical protein FLJ32844 DBR1 3q22.3 debranching enzyme homolog 1 (S. cerevisiae) HSPC056 3q22.3 HSPC056 protein TXL-2 3q22.3 thioredoxin-like 2 MRAS 3q22.3 muscle RAS oncogene homolog
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing polyA site 5200 130.3 1150 heart, brain, placenta, lung, skeletal muscle, kidney lowly Hendrix
    - splicing polyA site 2800 72 529 heart, skeletal muscle highly Hendrix
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • stretches of basic residues that may be putative nuclear localization signals (NLS)
  • a cluster of proline residues in an N terminal region common to both isoforms
  • HOMOLOGY
    interspecies ortholog to murine Ppp2r3
    homolog to C.elegans F56h9.5
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • modulating substrate selectivity and catalytic activity
  • directing the localization of the catalytic enzyme to a particular subcellular compartment
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • regulatory subunit of protein phosphatase 2a consisting of a common heterodimeric core enzyme composed of a 36 kDa catalytic subunit (subunit c) and a 65 kDa constant regulatory subunit (pr65 or subunit a) and associating with a variety of regulatory subunits (including three families of subunits b..)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS