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FLASH GENE
Symbol PPP2CB contributors: npt/ - updated : 07-08-2007
HGNC name protein phosphatase 2, catalytic subunit, beta isozyme
HGNC id 9300
Location 8p12      Physical location : 30.643.126 - 30.670.352
Synonym name
  • protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
  • serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform
  • Synonym symbol(s) PP2CB, PP2Abeta
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 27.23 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FBXO16 8p21.1 F-box only protein 16 FZD3 8p21 frizzled homolog 3 (Drosophila) EXTL3 8p21 exostoses (multiple)-like 3 FLJ10871 8p21.1 hypothetical protein FLJ10871 FLJ21616 8p21.1 hypothetical protein FLJ21616 KIF13B 8p21-p12 kinesin family member 13B DUSP4 8p12-p11 dual specificity phosphatase 4 LOC392208 8 similar to Ac2-210 LOC389645 8 LOC389645 MAP2K1P1 8p21 mitogen-activated protein kinase kinase 1 pseudogene 1 MGC8721 8p12 hypothetical protein MGC8721 LEPROTL1 8p21.2-p21.1 leptin receptor overlapping transcript-like 1 DCTN6 8p12-p11 dynactin 6 LOC392209 8 similar to heat shock protein (hsp-2) LOC92755 8p21.1 hypothetical gene LOC92755 RBPMS 8p12-p11 RNA binding protein with multiple splicing GTF2E2 8p12-p11 general transcription factor IIE, polypeptide 2, beta 34kDa GSR 8p21.1 glutathione reductase D8S2298E 8p12-p11.2 Homo sapiens reproduction 8 (D8S2298E), mRNA. PPP2CB 8p12-p11.2 protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform TEX15 8p12 testis expressed sequence 15 PURG 8p11 purine-rich element binding protein G WRN 8p12-p11.2 Werner syndrome LOC157589 8p12 similar to potassium channel tetramerisation domain containing 9 NRG1 8p21-p12 neuregulin 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1987 35 309 - -
  • a 7 exons variant
  • containing exon 1b (including variant 1 exons 1 & 2)
  • longer transcript
  • encoding for the same product as variant 1
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   moderately
    Hearing/Equilibriumearinnercochlea highly
    Nervousbrain   moderately
     nervecranial nerve  highly
    Urinarybladder   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Connectivebone  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • catalytic subunit containing a C terminal carboxyl group methylated by carboxyl methyltransferase
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Ppp2cb (100.00 pc)
    homolog to murine Ppp2cb (100.00 pc)
    Homologene
    FAMILY
  • PPP phosphatase family
  • PP-1 subfamily
  • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • protein phosphatase 2A, catalytic subunit
  • potential modulation of phosphorylase-b-kinase, casein kinase 2 and others
  • function as tumor suppressor protein, and important physiological regulator of cell growth and of cellular stress signaling (Lammers 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with a 65 kDa regulatory subunit
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Fe
  • Mn
  • protein
  • IGBP1
  • PME1
  • cell & other
    REGULATION
    Other negatively regulated by ISG15 conjugation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS