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FLASH GENE
Symbol PPP1R9B contributors: mct/pgu - updated : 03-01-2012
HGNC name protein phosphatase 1, regulatory subunit 9B, spinophilin
HGNC id 9298
Location 17q21.33      Physical location : 48.211.101 - 48.227.877
Synonym name
  • neurabin II
  • spinophilin
  • Synonym symbol(s) FLJ30345, PPP1R6, PPP1R9, SPINO, SPL
    DNA
    TYPE functioning gene
    STRUCTURE 16.78 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    GNGT2 17q21.3 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 NESH 17q21.3 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 PHOSPHO1 17q21.32 phosphatase, orphan 1 LOC124871 17q21.33 hypothetical gene LOC124871 KIAA0924 17q21.32 hypothetical gene LOC124871 PHB 17q21.3 prohibitin LOC388400 17 similar to Eukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit) NGFR 17q21.31 nerve growth factor receptor (TNFR superfamily, member 16) NXPH3 17q21.31 neurexophilin 3 SPOP 17q22 speckle-type POZ protein SLC35B1 17q21.3-q22 solute carrier family 35, member B1 LOC81558 17q21.33 C/EBP-induced protein MYST2 17q21.32 MYST histone acetyltransferase 2 TAC4 17 tachykinin 4 (hemokinin) LOC124865 17q21.33 similar to ribosomal protein P0-like protein; 60S acidic ribosomal protein PO; ribosomal protein, large, P0-like DLX4 17q21-q22 distal-less homeobox 4 DLX3 17q21.3-q22 distal-less homeo box 3 ITGA3 17q22-q23 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) PDK2 17q21.3 pyruvate dehydrogenase kinase, isoenzyme 2 LOC201191 17q21.33 hypothetical protein LOC201191 PPP1R9B 17q21-q22 protein phosphatase 1, regulatory subunit 9B, spinophilin SGCA 17q21 sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) HILS1 17q21.33 spermatid-specific linker histone H1-like protein COL1A1 17q21.31-q22.15 collagen, type I, alpha 1 FLJ33318 17q21.33 hypothetical protein FLJ33318 XYLT2 17q21.3-17q22 xylosyltransferase II MRPL27 17q21.3-q22 mitochondrial ribosomal protein L27 FLJ31364 PRO1855 17q21.33 hypothetical protein PRO1855 FLJ20920 17q21.33 hypothetical protein FLJ20920 MRPS21P9 17q21 mitochondrial ribosomal protein S21 pseudogene 9 CHAD 17q21.33 chondroadherin FLJ11164 17q21.33 hypothetical protein FLJ11164 DKFZp434N1415 17q21.33 Mycbp-associated protein EPN3 17q24.1 epsin 3 FLJ21347 17q21.33 hypothetical protein FLJ21347 LOC253962 17q21.33 hypothetical protein LOC253962 CACNA1G 17q22 calcium channel, voltage-dependent, alpha 1G subunit ABCC3 17q21.3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 MGC15396 17q21.33 hypothetical protein MGC15396 LUC7A 17q21 cisplatin resistance-associated overexpressed protein OA48-18 17q21.33 acid-inducible phosphoprotein FLJ20694 17q21.33 hypothetical protein FLJ20694 LOC390801 17 similar to S100 calcium-binding protein A10; S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)); annexin II ligand, calpactin I, light polypeptide WFIKKNRP 17q21.33 WFIKKN-related protein LOC390802 17 similar to ribosomal protein L5; 60S ribosomal protein L5 TOB1 17q21 transducer of ERBB2, 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4071 89.2 817 - 2000 10922077
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Nervousbrain   highly
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Nervouscentral  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • properties expected of a scaffolding protein localized to the cell membrane and a single consensus sequence in PSD95/DLG/ZO-1
  • a PDZ domain
  • HOMOLOGY
    interspecies homolog to C.elegans TO9A5.9
    Homologene
    FAMILY
    CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,nucleoplasm
    text dendritic spines
    basic FUNCTION
  • modulating both glutamatergic synaptic transmission and dendritic morphology
  • modulating PP1 enzymatic activity
  • enhancing DCX binding to F-actin
  • may be acting as a scaffold protein in multiple signaling pathways
  • PPP1R19A, and PPP1R19B reciprocally regulate Ca(2+) signaling by GPCRs
  • may play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction
  • may play analogous roles in information transfer at both neuronal and immunological synapses.
  • dendritic spine-enriched scaffold protein, modulating synaptic transmission via multiple functions mediated by distinct domains of the protein
  • key modulator of opiate action
  • potent physiological role in regulating OPRM1 function
  • required for synapse formation in the NK cells, suggesting that it may be involved in the maintenance of cellular architecture by regulation of actin assembly
  • regulates actin cytoskeletal organization and is required for hepatocyte growth factor-induced cell migration, in cooperation with SPATA13 and APC
  • its expression could enhance the regulatory function of RGS8 on the CHRM3, but the acceleration function of RGS8 on the M2-mediated signaling could not be enhanced by PPP1R9B
  • BAIAP2 and PPP1R9B regulate localized RAC1 activation by TIAM1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • regulatory subunit of protein phosphatase-1 catalytic subunit
  • PPP1R9B/PPP1R9A forms a functional pair of opposing regulators that modulates Ca(2+) signaling intensity by GPCRs by determining the extent of inhibition by the R4 family of RGS proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin, PP1, ARF (CDKN2A), playing a role in cell growth
  • binds to actin filaments (f-actin) and shows cross-linking activity
  • at the cellular level, spinophilin associates with OPRM1 in striatum and modulates OPRM1 signaling and endocytosis
  • binds along the sides of the f-actin
  • interacting with SPATA13
  • PPP1R9B is a RGS8-interacting protein (CHRM1 and PPP1R9B compete for binding to RGS8)
  • two TIAM1-interacting proteins in fibroblasts, insulin receptor substrate protein 53 kDa (BAIAP2) and PPP1R98B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    combined loss of PPP1R9B and mutant TP53 activity led to increased mammary carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatry  
    potential new target for the treatment of opiate addiction
    ANIMAL & CELL MODELS
    spinophilin knockout mice