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FLASH GENE
Symbol PPP1R8 contributors: mct/npt - updated : 11-02-2009
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 8
HGNC id 9296
Location 1p35.3      Physical location : 28.157.292 - 28.178.183
Synonym name
  • activator of RNA decay 1
  • nuclear inhibitor of protein Ser/Thr phosphatase-1
  • RNase E
  • nuclear subunit of PP-1
  • Synonym symbol(s) ARD1, NIPP1, PRO2047, NIPP-1
    EC.number 3.1.4.-
    DNA
    TYPE functioning gene
    STRUCTURE 20.90 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ10349 1p35.3 hypothetical protein FLJ10349 FLJ12455 1p35.3-p35.1 hypothetical protein FLJ12455 NR0B2 1p36.1 nuclear receptor subfamily 0, group B, member 2 NUDC 1p35-p34 nuclear distribution gene C homolog (A. nidulans) FLJ34633 1p35.3 hypothetical protein FLJ34633 LOC391022 1 similar to DC2 protein LOC388610 1 LOC388610 MGC16491 1p35.3 hypothetical protein MGC16491 SLC9A1 1p35 solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive) LOC391023 1 similar to ribosomal protein L18a; 60S ribosomal protein L18a LOC284609 1p35.3 similar to hypothetical protein FLJ20420 LOC148356 1p35.3 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 WDTC1 1p35.3 WD and tetratricopeptide repeats 1 DKFZP564D0478 1p35.3 hypothetical protein DKFZp564D0478 JFC1 1p35.3 hypothetical protein DKFZp564D0478 MAP3K6 1p35.2 mitogen-activated protein kinase kinase kinase 6 FCN3 1p36-p32 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen) LOC388611 1 similar to EAPG6122 GPR3 1p35.1-p34.3 G protein-coupled receptor 3 WASF2 1p36.11-p34.3 WAS protein family, member 2 DJ159A19.3 1p36.13 hypothetical protein DJ159A19.3 LOC388612 1 LOC388612 FGR 1p35 Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog G1P3 1p35 interferon, alpha-inducible protein (clone IFI-6-16) LOC339409 1p35.3 similar to Procollagen (type III) N-endopeptidase MGC34648 1p35.3 hypothetical protein MGC34648 STX12 1p35-p34.1 syntaxin 12 PPP1R8 1p35 protein phosphatase 1, regulatory (inhibitor) subunit 8 C1orf38 1p35.2 chromosome 1 open reading frame 38 RPA2 1p35 replication protein A2, 32kDa ASML3B 1p35.2 acid sphingomyelinase-like phosphodiesterase FLJ10307 1p35.2 hypothetical protein FLJ10307 EYA3 1p36 eyes absent homolog 3 (Drosophila) LOC388613 1 similar to Microsomal signal peptidase 25 kDa subunit (SPase 25 kDa subunit) (SPC25) LOC391024 1 similar to RIKEN cDNA 2610313E07 PTAFR 1p35.1-p34.3 platelet-activating factor receptor DNAJC8 1p35.3 DnaJ (Hsp40) homolog, subfamily C, member 8 ATPIF1 1p35.3 ATPase inhibitory factor 1 SESN2 1p35.3 sestrin 2 FLJ20045 1p35.2 TRAP/mediator complex subunit p28b FLJ13171 1p35 TRAP/mediator complex subunit p28b CHC1 1p36.1 chromosome condensation 1 SECP43 1p35.2 tRNA selenocysteine associated protein LOC85028 1p35.2 PNAS-123
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 2336 38 351 - Van Eynde, Nuytten (2008)
    seven exons
    7 splicing 2691 - 209 brain, heart, kidney Van Eynde, Nuytten (2008)
    6 splicing 2590 13.3 127 B-cells, t-lymphocytes and 293 embryonic kidney cells Wang, Nuytten (2008)
  • implicated in mRNA splicing
  • site-specific single-strand endonuclease
  • mostly cytoplasmic
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunethymus   highly
    Nervousbrain    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumcardiac  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid ,basic
    STRUCTURE
    motifs/domains
  • a basic N and C-terminal
  • an acidic central domains
  • a FHA domain
  • a C-terminal fragment displaying an RNase E like endoribonuclease activity
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to C.elegans B0511.7
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • type 1 serine/threonine specific protein phosphatase inhibitor, involved in a late step of spliceosome assembly
  • playing a role as a DNA-targeting protein for EED and associated chromatin-modifying enzymes
  • nuclear scaffold protein implicated in both transcription and RNA processing
  • playing an indispensable role for early embryonic development and cell proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    RNA catabolism (RNA turnover)
    a component
  • inhibitor subunit of the major nuclear protein phosphatase-1 (pp.1)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Mg2+
  • protein
  • interacting with PP1
  • interacting with the splicing factors SAP155 and CDC5L
  • NIPP1-EED interaction potentiated by the binding of (d)G-rich nucleic acids to the central domain of PPP1R8
  • promotes SF3B1 dephosphorylation (specifically recognizes hyperphosphorylated SF3B1 thorough its Forkhead-associated domain and dissociates from SF3B1 after dephosphorylation by associated protein phosphatase-1)
  • associates with a subset of PcG (Polycomb group) targets in a PP1-dependent manner and thereby contributes to the recruitment of the PRC2 complex
  • cell & other
    REGULATION
    inhibited by downregulated by phosphorylation
    Other tightly regulated by phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung, colorectal, gastric, ovarian carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS