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FLASH GENE
Symbol PPP1R3D last update : 24-05-2005
HGNC name protein phosphatase 1, regulatory subunit 3D
HGNC id 9294
Location 20q13.3
Synonym name protein phosphatase 1, regulatory subunit 6, spinophilin
Synonym symbol(s) PPP1R6
EC.number 3.1.3.16
DNA RNA EXP/sub-loc PROTEIN PATHOLOGY
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
C20orf85 20q13.32 chromosome 20 open reading frame 85 C20orf86 20q13.32 chromosome 20 open reading frame 86 PPP4R1L 20q13.32 protein phosphatase 4, regulatory subunit 1-like RAB22A 20q13 RAB22A, member RAS oncogene family VAPB 20q13 VAMP (vesicle-associated membrane protein)-associated protein B and C FLJ90166 20q13.32 hypothetical protein FLJ90166 MGC4294 20q13.32 hypothetical protein MGC4294 LOC388801 20 LOC388801 STX16 20q13.32 syntaxin 16 NPEPL1 20q13.32 aminopeptidase-like 1 LOC388802 20 hypothetical gene supported by AK124059 LOC391258 20 similar to Hypothetical protein KIAA0233 GNAS 20q13.2-q13.3 GNAS complex locus TH1L 20q13 TH1-like (Drosophila) CTSZ 20q13 cathepsin Z TUBB1 20q13.32 tubulin, beta 1 ATP5E 20q13.2-q13.3 ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit C20orf45 20q13.32 chromosome 20 open reading frame 45 MRPS16P 20q13.32 chromosome 20 open reading frame 45 LOC343629 20q13.32 similar to bA379F14.2 (novel protein) C20orf174 20q13.32 chromosome 20 open reading frame 174 EDN3 20q13.2-q13.3 endothelin 3 LOC391259 20 similar to bA164D18.1 (novel protein similar to KIAA0233) SCAPIN1 20q13.32-q13.33 scapinin SYCP2 20q13.33 synaptonemal complex protein 2 PPP1R3D 20q13.3 protein phosphatase 1, regulatory subunit 3D C20orf177 20q13.2-q13.33 chromosome 20 open reading frame 177 CDH26 20q13.2-q13.33 cadherin-like 26 FLJ33860 20q13.33 hypothetical protein FLJ33860 LOC388803 20 LOC388803 LOC388804 20 LOC388804 MTCO2L 20 cytochrome c oxidase II-like LOC128629 20q13.33 similar to hypothetical protein LOC391260 20 similar to cadherin 4, type 1 preproprotein; cadherin 4, R-cadherin (retinal); R-cadherin; retinal cadherin
RNA
TRANSCRIPTS number of transcripts 2 type messenger
identificationnb exonstypebpproduct
kDaAAspecific expressionauthor
long isoform - - 5400
- - widely Armstrong
-
short isoform - - 3800
- - widely Armstrong
-
EXPRESSION / SUBCELLULAR LOCALIZATION
EXPRESSION (based on citations) ubiquitous
constitutive of
   expressed in
organ(s)
SystemOrgan 1organ 2organ 3organ 4level
Cardiovascularheart   highly
Nervousbrain    
tissue
SystemTissueS_TissueSs_Tissuelevel
Muscularstriatumcardiac  
Nervousperipherous   
cells
SystemCell
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
SUBCELLULAR LOCALIZATION     plasma membrane
text dendritic spines
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single consensus sequence in PSD95/DLG/ZO-1 and properties expected of a scaffolding protein localized to the cell membrane
    • HOMOLOGY
    interspecies
     
    		 homolog to murine Ptg
    intraspecies
     
    Homologene
    FAMILY
    CATEGORY chaperone/stress , enzyme , regulatory
    basic FUNCTION
  • serine/threonine protein phosphatase, modulator of PP1 enzymatic activity
  • glycogen targeting subunit 6 of protein phosphatase 1
    • implicated in a
    process
    cellular process
    physiological
    pathway
    metabolism
    signaling
    a component
    structural
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1
  • interacting with ADRA2B (contributing to cell surface stabilization of the receptor)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Therapy target
    animal or cellular model