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FLASH GENE
Symbol PPP1R3B contributors: mct/npt - updated : 13-04-2010
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 3B
HGNC id 14942
Location 8p23.1      Physical location : 8.993.773 - 9.008.220
Synonym name
  • protein phosphatase 1,hepatic glycogen-targeting subunit GL
  • hepatic glycogen-targeting protein phosphatase 1 regulatory
    • subunit GL
  • protein phosphatase 1 subunit GL
    • Synonym symbol(s) GL, PPP1R4, FLJ14005, FLJ34675, R4
    DNA
    TYPE functioning gene
    STRUCTURE 14.45 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392186 8 similar to hypothetical protein LOC169270 LOC392187 8 similar to ubiquitin-specific protease 17-like protein LOC392188 8 similar to ubiquitin-specific protease 17-like protein LOC392189 8 similar to ubiquitin-specific protease 17-like protein LOC389620 8 similar to hypothetical protein FLJ10408 LOC340407 8p23.1 similar to FLJ10408 protein LOC389621 8 similar to seven transmembrane helix receptor LOC392190 8 similar to chromosome 11 open reading frame2; chromosome 11 open reading frame2 LOC389622 8 hypothetical gene supported by AK124896; BC037255; BC038200 LOC286042 8p23.1 similar to Alkaline sphingomyelinase LOC392191 8 similar to mannosyltransferase DKFZp761P0423 8p23.1 hypothetical protein DKFZp761P0423 CLDN23 8p23.1 claudin 23 MFHAS1 8p23.1 malignant fibrous histiocytoma amplified sequence 1 MRPS18CP2 8p23.1 mitochondrial ribosomal protein S18C pseudogene LOC392192 8 similar to 60S ribosomal protein L10 (QM protein homolog) RNU7P4 8p23.1 RNA, U7 small nuclear pseudogene 4 PPP1R3B 8p23.1 protein phosphatase 1, regulatory (inhibitor) subunit 3B TNKS 8p11 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase LOC389623 8 LOC389623 MSRA 8p23.1 methionine sulfoxide reductase A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 5564 - 285 - Doherty (1995)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver   highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal PP1-binding motif (RVSF) motif
  • a central glycogen-binding region
  • a C-terminal binding region for phosphorylase
    • HOMOLOGY
    intraspecies homolog to PPP1R3E,PPP1R3F,PPP1R3G
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be contributing to the insulin-stimulated phosphatase activity in skeletal muscle
  • serine/threonine phosphatase involved in the modulation of glycogen synthesis in the liver and skeletal muscle (Dunn 2006)
  • target PP1 to glycogen and regulate its activity on enzymes of glycogen metabolism (Niimi 2007)
  • activates glycogen synthase regardless of glucose, does not regulate glycogen phosphorylase and stimulates glycogenesis in combination with insulin and glucose depletion (Montori-Grau 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycogen metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1
    • cell & other
    REGULATION
    activated by insulin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS