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FLASH GENE
Symbol PPP1R3B contributors: mct/npt - updated : 13-04-2010
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 3B
HGNC id 14942
Location 8p23.1      Physical location : 8.993.773 - 9.008.220
Synonym name
  • protein phosphatase 1,hepatic glycogen-targeting subunit GL
  • hepatic glycogen-targeting protein phosphatase 1 regulatory
  • subunit GL
  • protein phosphatase 1 subunit GL
  • Synonym symbol(s) GL, PPP1R4, FLJ14005, FLJ34675, R4
    DNA
    TYPE functioning gene
    STRUCTURE 14.45 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 5564 - 285 - Doherty (1995)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver   highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal PP1-binding motif (RVSF) motif
  • a central glycogen-binding region
  • a C-terminal binding region for phosphorylase
  • HOMOLOGY
    intraspecies homolog to PPP1R3E,PPP1R3F,PPP1R3G
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be contributing to the insulin-stimulated phosphatase activity in skeletal muscle
  • serine/threonine phosphatase involved in the modulation of glycogen synthesis in the liver and skeletal muscle (Dunn 2006)
  • target PP1 to glycogen and regulate its activity on enzymes of glycogen metabolism (Niimi 2007)
  • activates glycogen synthase regardless of glucose, does not regulate glycogen phosphorylase and stimulates glycogenesis in combination with insulin and glucose depletion (Montori-Grau 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycogen metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1
  • cell & other
    REGULATION
    activated by insulin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS