Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | PPP1R3A | contributors: - updated : 08-12-2004 |
HGNC name | protein phosphatase 1, regulatory (inhibitor) subunit 3A (glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle) |
HGNC id | 9291 |
|
Corresponding disease |
| ||||||
Location | 7q11.23 Physical location : 113.516.881 - 113.559.082 | ||||||
Synonym name | protein phosphatase 1, glycogen associated | ||||||
Synonym symbol(s) | PPP1R3, PP1G | ||||||
EC.number | 3.1.3.16 |
DNA |
TYPE | functioning gene |
STRUCTURE | 44.00 kb 4 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
---|
MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
---|
|
EXPRESSION |
Type | restricted |
constitutive of |
expressed in | (based on citations) |
organ(s) |
tissue |
|
cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
|
mono polymer | heteromer , dimer |
HOMOLOGY |
interspecies | homolog to murine Ppp1r3a |
Homologene |
FAMILY |
CATEGORY | enzyme , regulatory |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth | |
text | sarcoplasmic reticulum |
basic FUNCTION | regulating phosphatase activity towards glycogen synthase (glycogen synthesis) |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism | carbohydrate |
signaling |
a component | heterodimerizing with a 37kDa catalytic subunit |
INTERACTION |
DNA |
RNA |
small molecule | other, |
protein | glycogen synthase |
cell & other |
REGULATION |
activated by | phosphorylation at Ser 46 in response to insulin |
induced by | phosphorylation at Ser 65 in response to adrenaline causing dissociation of the catalytic subunit from the G subunit |
ASSOCIATED DISORDERS |
corresponding disease(s) | PPARG , DIDAN , FPLD3 |
Susceptibility |
Variant & Polymorphism
| |
Candidate gene
Marker
| Therapy target
|
| |
ANIMAL & CELL MODELS |