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FLASH GENE
Symbol PPP1R1C contributors: npt - updated : 02-02-2010
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 1C
HGNC id 14940
Location 2q31.3      Physical location : 182.850.550 - 182.982.418
Synonym name
  • inhibitor-1-like
  • protein phosphatase 1 regulatory subunit 1A
  • inhibitor-5 of protein phosphatase 1
  • PP1 inhibitor protein 5
  • Synonym symbol(s) ARRP21, IPP5
    DNA
    TYPE functioning gene
    STRUCTURE 131.87 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1014 12 109 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   moderately
    Endocrinethyroid   predominantly
    Hearing/Equilibriumear   highly
    Reproductivemale systemtestis  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticthymocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ARRP21 domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Ppp1r1c (85.2 pc)
    Homologene
    FAMILY
  • protein phosphatase inhibitor 1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • acting as an inhibitor of protein-phosphatase 1
  • promoting tumor cell growth and cell cycle progression by acting as an inhibitory molecule for PP1
  • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the PP1 catalytic subunit
  • cell & other
    REGULATION
    activated by phosphorylation on Thr-40 by protein kinase A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS