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FLASH GENE
Symbol PPP1R1B contributors: mct/npt - updated : 19-07-2008
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 1B
HGNC id 9287
Location 17q21.2      Physical location : 37.783.178 - 37.792.875
Synonym name
  • dopamine and cAMP-regulated phosphoprotein of 32 kDa
  • protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)
  • Synonym symbol(s) DARPP-32, DARPP32, FLJ20940
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 97.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388381 17 LOC388381 RPL23 17q12 ribosomal protein L23 LASP1 17q12-q21 LIM and SH3 protein 1 LOC388382 17 hypothetical gene supported by BC009632; BC042124 FLJ43826 17q21.2 FLJ43826 protein PLXDC1 17q21.1 plexin domain containing 1 LOC390790 17 similar to Cg7197-prov protein CACNB1 17q21 calcium channel, voltage-dependent, beta 1 subunit RPL19 17q11 ribosomal protein L19 24b2/STAC2 17q21.2 24b2/STAC2 protein LOC388383 17 similar to upstream binding protein 1 MGC15482 17q21.2 F-box protein FBL2 PPARBP 17q12-q21.1 PPAR binding protein CRK7 17q21.2 CDC2-related protein kinase 7 NEUROD2 17p13.1 neurogenic differentiation 2 PPP1R1B 17q21.2 protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32) STARD3 17q21.1 START domain containing 3 TCAP 17q12-q21.1 titin-cap (telethonin) PNMT 17q21.1 phenylethanolamine N-methyltransferase CAB2 17q21.2 CAB2 protein ERBB2 17q11.2-q12 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) MGC14832 GRB7 17q11.2-q12 growth factor receptor-bound protein 7 ZNFN1A3 17q11.2 zinc finger protein, subfamily 1A, 3 (Aiolos) ZPBP2 17q21.2 zona pellucida binding protein 2 GSDML 17q21.2 gasdermin-like ORMDL3 17q12 ORM1-like 3 (S. cerevisiae) LOC342669 17q21.2 similar to leucine-rich repeat domain-containing protein GSDM 17q21.2 gasdermin PSMD3 17q21.1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 CSF3 17q11.2-q12 colony stimulating factor 3 (granulocyte) TRAP100 THRA 17q11.2 thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) NR1D1 17q11.2 nuclear receptor subfamily 1, group D, member 1 MLN51 17q12-q21.3 nuclear receptor subfamily 1, group D, member 1 LOC339287 17q21.2 hypothetical protein LOC339287 Link-GEFII 17q21.2 Link guanine nucleotide exchange factor II WIRE 17q21.2 WIRE protein CDC6 17q21.3 CDC6 cell division cycle 6 homolog (S. cerevisiae)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1841 - 204 expressed in medium-sized spiny neurons and overexpressed in gastric carcinoma Beckler, Belkhiri (2008)
    - - 1502 - 168 overexpressed in gastric cancers EL Rifai, Belkhiri (2008)
  • lacks the phosphorylation site related to protein phosphatase 1 inhibition but maintains the phosphorylation site with the protein kinase A inhibitory effect
  • promotes cancer cell survival by up-regulation of BCL2 through AKT-dependent mechanism
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
     stomach   highly
    Nervousbrainbasal nucleicaudate nucleus highly
     brainforebraincerebral cortex highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated Other
    HOMOLOGY
    interspecies homolog to murine Ppp1r1b
    homolog to C.elegans T23B3.5
    Homologene
    FAMILY
  • protein phosphatase inhibitor 1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • mainly nuclear when Ser 97 is dephosphorylated, whereas it is preferentially cytoplasmic when phosphorylated by CNSK2A1
  • drugs of abuse and food self-administration induce nuclear accumulation in striatal neurons
  • basic FUNCTION
  • inhibitor of protein phosphatase 1 and PKA
  • playing a central role in regulating the efficacy of dopaminergic neurotransmission
  • a key factor in the phosphorylation of histone H3, a component of the nucleosomal response that is essential for gene expression
  • may be a tumor suppressor in oral premalignant and malignant lesions
  • playing a role in the interactions of dopamine and glutamate in the neostriatum
  • antiapoptotic gene in upper gastrointestinal carcinomas
  • may be a tumor suppressor in in oral premalignant and malignant lesions
  • dual-function protein kinase/phosphatase inhibitor that is involved in striatal signaling
  • pivotal integrator of information in dopaminoceptive neurons, regulating the response to neuroleptics, psychotomimetics, and drugs of abuse, and affecting striatal function and plasticity (Meyer-Lindenberg 2007)
  • might mediate multidrug resistance of gastric cancer through regulation of permeability glycoprotein (P-gp) and ZNRD1 (Hong 2007)
  • plays a pivotal role in cognitive function and possibly in the pathogenesis of schizophrenia (Meyer-Lindenberg 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1
  • changes the usage of TRA2B dependent alternative exons in a concentration-dependent manner, suggesting that the PPP1R1B:TRA2B interaction is a molecular link between signaling pathways and pre-mRNA processing
  • cell & other
    REGULATION
    activated by CAMP dependent phosphorylation produced by dopamine stimulation
    inhibited by NMDA-induced dephosphorylation
    Other phosphorylation on threonine 75 by CDK5 leads PPP1R1B inhibitor of PKA
    phosphorylation on threonine 34 by PKA leads to PPP1R1B inhibitor of protein phosphatase 1
    regulated by glutamate in neostriatal neurons involving activation of multiple signaling cascades
    phosphorylation at threonine 34 is essential for mediating the effects of both psychostimulant and antipsychotic drugs
    regulation of its phosphorylation in striatal neurons, by cocaine and haloperidol and a variety of agents
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in leukoplakia, and oral squamous cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target regulation of the nuclear accumulation of PPP1R1B may be important to the functions or dysfunctions of dopamine that involve transcription-dependent long-term plasticity, including neuroleptic- and L-DOPA-induced dyskinesia, and other diseases of the basal ganglia
    ANIMAL & CELL MODELS
    Darpp 32 knockout mice