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FLASH GENE
Symbol PPP1R14D contributors: SGE/npt - updated : 06-04-2010
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 14D
HGNC id 14953
Location 15q15.1      Physical location : 41.107.644 - 41.120.907
Synonym name
  • PKC-dependent PP1 inhibitory protein
  • gut and brain phosphatase inhibitor 1
  • gastrointestinal and brain-specific PP1-inhibitory protein 1
  • Synonym symbol(s) CPI17-like, FLJ20251, GBPI-1, MGC119014, GBPI1, MGC119016
    DNA
    TYPE functioning gene
    STRUCTURE 13.27 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 880 - 200 - Liu (2004)
    4 - 764 - 145 - Liu (2004)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
     stomach    
    Nervousbrainforebraincerebral cortex  
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a consensus PP1-binding motif at residues 21-25
  • consensus sites for phosphorylation by enzymes, including PKC, PKA
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Ppp1r14d (82.8pc)
    homolog to rattus Ppp1r14d (80.7pc)
    Homologene
    FAMILY
  • PP1 inhibitor family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing important roles at the junctions between PKC and PKA phosphoregulatory pathways in tissues such as brain, gut and testis
  • inhibitory activity only when phosphorylated by PKC, thus creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1
  • cell & other
    REGULATION
    activated by PKC phosphorylation
    inhibited by PKA
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS