Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | PPP1R14A | contributors: mct - updated : 06-04-2011 |
HGNC name | protein phosphatase 1, regulatory (inhibitor) subunit 14A |
HGNC id | 14871 |
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Location | 19q13.13 Physical location : 38.741.878 - 38.747.172 |
Synonym name | |
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Synonym symbol(s) | CPI-17, PPP1INL |
DNA |
TYPE | functioning gene |
SPECIAL FEATURE | arranged in tandem |
STRUCTURE | 5.30 kb 4 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
Text | expressed in embryonic heart |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
| N terminal 67 residues highly conserved |
conjugated | PhosphoP |
HOMOLOGY |
interspecies | homolog to murine Ppp1r14a |
Homologene |
FAMILY | PP1 inhibitor family |
CATEGORY | protooncogene |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
Other | phosphorylated by PKN |
cooperative increases in Ca2+ and G protein activation are required for a significant activation of total kinases that phosphorylate PPP1R14A, which together overcome PPP1R14A phosphatase activity and effectively increase the Ca2+ sensitivity of PPP1R14A phosphorylation and smooth muscle contraction |
ASSOCIATED DISORDERS |
ANIMAL & CELL MODELS |