Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PPP1R13B contributors: mct - updated : 13-02-2008
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 13B
HGNC id 14950
Location 14q32.33      Physical location : 104.200.087 - 104.313.927
Synonym name apoptosis stimulating protein of p53, 1
Synonym symbol(s) p85, KIAA0771, p53BP2-like, ASPP1
DNA
TYPE functioning gene
STRUCTURE 113.84 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
C14orf73 14 chromosome 14 open reading frame 73 TNFAIP2 14q32 tumor necrosis factor, alpha-induced protein 2 RPL21P12 14q32.33 ribosomal protein L21 pseudogene 12 RPL21P13 14 ribosomal protein L21 pseudogene 13 RPL17P4 14 ribosomal protein L17 pseudogene 4 LOC388019 14 LOC388019 EIF5 14q32.33 eukaryotic translation initiation factor 5 LAMR1P5 14 laminin receptor 1 pseudogene 5 MARK3 14q32.3 MAP/microtubule affinity-regulating kinase 3 RPL10AP1 14 ribosomal protein L10a pseudogene 1 CKB 14q32.32 creatine kinase, brain FLJ40452 14q32.33 hypothetical protein FLJ40452 BAG5 14q32.32 BCL2-associated athanogene 5 MGC2562 14q32.33 hypothetical protein MGC2562 KNS2 14q32.3 kinesin 2 60/70kDa XRCC3 14q32.3 X-ray repair complementing defective repair in Chinese hamster cells 3 ZFYVE21 14q32.33 zinc finger, FYVE domain containing 21 PPP1R13B 14q32.33 protein phosphatase 1, regulatory (inhibitor) subunit 13B C14orf2 14q32.33 chromosome 14 open reading frame 2 LOC338934 14q32.33 similar to chromosome 1 open reading frame 36 C14orf75 14q32.33 chromosome 14 open reading frame 75 LOC374569 14q32.33 Similar to Lysophospholipase KIF26A 14q32.33 kinesin family member 26A LOC390507 14 similar to proline-rich glycoprotein (sgp158)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 4976 - 1090 - 2006 16314841
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly
Endocrinethyroid   highly
Nervousbrain   moderately
Reproductivefemale systemovary  moderately
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal beta-GRASP ubiquitin-like fold suggesting a possible role in binding to other proteins in the apoptotic response network and thus mediating their selective pro-apoptotic functiona proline-rich sequence
  • ankyrin repeats
  • SH3 domain and proline-rich domains
  • HOMOLOGY
    intraspecies homolog to TP53BP2/ASPPZ
    Homologene
    FAMILY
  • ASPP family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • enhancing TP53-induced apoptosis
  • enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic gene
  • regulating the tumor suppression function of TP53
  • having ability to regulate the apoptotic function of TP53 and its family members, TP63 and TP73
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding directly to p53, p63 and p73
  • transcriptional targets of E2F1 (provides another mechanism by which E2F cooperates with TP53 to induce apoptosis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type TP53
    tumoral     --low  
    frequently downregulated in in breast carcinomas expressing wild type TP53 (not with mutant TP53)
    tumoral       loss of function
    by aberrant methylation of its promoter in acute lymphoblastic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    target for cancer therapy
    ANIMAL & CELL MODELS