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FLASH GENE
Symbol PPP1R11 contributors: mct/ - updated : 18-04-2005
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 11
HGNC id 9285
Location 6p22.1      Physical location : 1.275.162 - 30.038.106
Synonym name
  • hemochromatosis candidate gene V
  • t-complex-associated-testis-expressed 5
  • protein phosphatase inhibitor 3
  • inhibitor-3
  • Synonym symbol(s) HCG-V, TCTE5, HCGV, Tctex5, IPP3, MGC125741, MGC125742, MGC125743
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 3.18 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see HFEC@
    Physical map
    P5-05 6p21.3 P5-1 pseudogene HLA-K 6p21.3 major histocompatibility complex, class I, K HLA-21 6p21.3 HLA-21 pseudogene P5.8 6p21.3 P5-1 pseudogene HCGIV-05 HLA-A 6p21.3 major histocompatibility complex, class I, A P5-03 HCGIV-04 HLA-80 6p21.3 HLA-80 pseudogene HCGII-6 MICD 6p21.3 MHC class I polypeptide-related sequence D HCGIX 3.8-1.2 6p21.3 3.8-1.2 pseudogene P5-02 HLA-J 6p21.3 major histocompatibility complex, class I, J (pseudogene) ETF1P1 6p21.3 eukaryotic translation termination factor 1 pseudogene 1 C6orf12 6p22.1 chromosome 6 open reading frame 12 ZNRD1 6p21.3 zinc ribbon domain containing, 1 PPP1R11 6p21.3 protein phosphatase 1, regulatory (inhibitor) subunit 11 RNF39 6p21.3 ring finger protein 39 TRIM31 6p21.3 tripartite motif-containing 31
    regionally located . belonging to a cluster of genes in the MHC1 region (see HFEC@), 150 kb centrometric to the HLA-A gene
    RNA
    TRANSCRIPTS type messenger
    text existence of the least 1 spliced form (PMID: 8938444)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1664 - 126 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text tissues
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • eight potential phosphorylation sites
  • a C terminal PEST pattern
  • a VxW motif
  • HOMOLOGY
    interspecies homolog to murine Tctex 5/Ppp1r11
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • protein phosphatase inhibitor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • t complex associated
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • reciprocal relationship between the levels of the PPP1CC and its regulator PPP1R11, suggesing that complex formation between these polypeptides in testis may prevent proteolysis of PPP1R11 and thus, germ cell apoptosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS