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FLASH GENE
Symbol PPOX contributors: mct - updated : 22-05-2013
HGNC name protoporphyrinogen oxidase
HGNC id 9280
Corresponding disease
VP1 variegata porphyria 1
Location 1q23.3      Physical location : 161.136.180 - 161.141.010
Synonym symbol(s) PPO, V290M, MGC8485
EC.number 1.3.3.4
DNA
TYPE functioning gene
STRUCTURE 4.83 kb     13 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
text two transcripts encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1716 50.6 477 - 2008 18191920
13 - 1777 50.6 477 - 2008 18191920
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrineneuroendocrinepituitary  highly
 pancreas    
Lymphoid/Immunethymus   highly
 tonsils   highly
Reproductivefemale systemuterus  highly
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal independently functioning signal for mitochondrial targeting, and all the information required for efficient import is contained within the first 250 AAs of N-terminus
  • conjugated FlavoP
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • protoporphyrinogen oxidase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,membrane
    text
  • nucleus-encoded flavoprotein strongly associated with the outer surface of the inner mitochondrial membrane
  • basic FUNCTION
  • protoporphyrinogen oxidase, catalyzing protoporphyrin formation, seventh step of porphyrin biosynthesis
  • mitochondrial inner membrane protein, converting protoporphyrinogen IX to protoporphyrin IX in the heme biosynthetic pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • one FAD per homodimer
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) VP1
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS