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FLASH GENE
Symbol PPME1 contributors: mct - updated : 08-07-2011
HGNC name protein phosphatase methylesterase 1
HGNC id 30178
Location 11q13.4      Physical location : 73.882.367 - 73.965.747
Synonym name protein phosphatase methylesterase-1
Synonym symbol(s) PME-1, FLJ22226, PP2593
EC.number 3.1.1.-
DNA
TYPE functioning gene
STRUCTURE 83.00 kb     14 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2484 42 386 - 1999 10318862
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
 mouthtongue  highly
 stomach   predominantly
Lymphoid/Immunethymus   moderately
Reproductivefemale systemuteruscervix highly
 female systembreastmammary gland highly
 female systemovary  moderately
 male systemtestis  moderately
Visualeye   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • AB hydrolase superfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • predominantly localized in the nucleus and harbors a functional nuclear localization signal
  • basic FUNCTION
  • demethylating proteins that have been reversibly carboxymethylated
  • acting as a protein phosphatase inhibitor
  • acting as a serine esterase
  • stabilization of the inactive, nuclear PPP2CA pool is a major function of PPME1
  • PPME1-mediated inhibition of the protein phosphatase 2A promotes basal ERK pathway activity and is required for efficient growth factor response
  • its expression is one mechanism by which ERK pathway activity is maintained in cancer cells, suggesting an important functional role for PME-1 in the disease progression of astrocytic gliomas
  • regulation of protein phosphatase 2A methylation by LCMT1 and PPME1 plays a critical role in differentiation of neuroblastoma cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    aromatic compound metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PPP2CB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • targeted disruption of the Ppme1 gene causes loss of demethylated Ppp2r4 and perinatal lethality in mice