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FLASH GENE
Symbol PPM1L contributors: - updated : 17-05-2006
HGNC name protein phosphatase 1 (formerly 2C)-like
HGNC id 16381
Location 3q26.1      Physical location : 160.473.995 - 160.788.813
Synonym name protein phosphatase 2C epsilon
Synonym symbol(s) PP2CE, PP2C-epsilon
DNA
TYPE functioning gene
STRUCTURE 228.00 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
LOC339892 3q25.31 similar to Death domain containing protein CRADD (Caspase and RIP adaptator with death domain) (RIP associated protein with a death domain) CCNL1 3q26.1 cyclin L1 LOC391589 3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) FLJ12604 3q24-q25 hypothetical protein FLJ12604 PTX3 3q21-q25 pentaxin-related gene, rapidly induced by IL-1 beta LOC152078 3q25.32 hypothetical protein BC010062 SHOX2 3q25-q26.1 short stature homeobox 2 MGC12197 3q25.32 BM-011 protein MLF1 3q25.1 myeloid leukemia factor 1 EFG1 3q25.1-q26.2 myeloid leukemia factor 1 LXN 3q25-q31 myeloid leukemia factor 1 RARRES1 3q25.31 retinoic acid receptor responder (tazarotene induced) 1 FLJ14153 3q25.32 hypothetical protein FLJ14153 GPR79 3q26 G protein-coupled receptor 79 pseudogene SCHIP1 3q25.3-q27 schwannomin interacting protein 1 IL12A 3q25.1-q25.3 interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) LOC389171 3 similar to bromodomain containing 7; bromodomain protein; bromodomain-containing 7 LOC391590 3 similar to hypothetical protein KIAA1374 3q25.33-q26.1 KIAA1374 protein SMC4L1 3q26.1 SMC4 structural maintenance of chromosomes 4-like 1 (yeast) TSBF1 3q26.1 tumor suppressor TSBF1 KPNA4 3q25.33 karyopherin alpha 4 (importin alpha 3) LOC90133 3q26.1 hypothetical protein LOC90133 FLJ22595 3q26.1 hypothetical protein FLJ22595 LOC389172 3 LOC389172 PPM1L 3q26.1 protein phosphatase 1 (formerly 2C)-like B3GALT3 3q25 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3 CGI-07 3q26.1 CGI-07 protein ADMP 3q26.1 ADMP LOC285214 3q26.1 similar to 60S ribosomal protein L23a LOC131149 3q26.1 similar to otolin-1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveliver   highly
Nervousbrain   highly
Reproductivemale systemtestis   
Respiratorylung   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a PP2C-like domain
HOMOLOGY
interspecies ortholog to murine Ppm1l
ortholog to rattus Ppm1l
Homologene
FAMILY PP2C family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • ser/thr protein phosphatase activity
  • may have a role in the regulation of IL1-TAK1 signaling pathway via its interaction with TAK1 and its dephosphorylation, maintaining it in an inactive state
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Mg2+ or Mn2+ dependent phosphatase activity
    protein
  • associates stably with TAK1
    • cell & other
    REGULATION
    Other dissociates from TAK1 by IL1 treatment
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS