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FLASH GENE
Symbol PPM1F contributors: mct - updated : 17-07-2008
HGNC name protein phosphatase 1F (PP2C domain containing)
HGNC id 19388
Location 22q11.22      Physical location : 22.273.791 - 22.307.250
Synonym name
  • PP2C phosphatase
  • partner of PIX 2
  • CaM-kinase phosphatase
  • Ca(2+)/calmodulin-dependent protein kinase phosphatase
  • Synonym symbol(s) FEM-2, POPX2, CaMKPase, KIAA0015, CAMKP
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 33.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC150223 22q11.22 hypothetical protein LOC150223 FLJ36046 22q11.22 hypothetical protein FLJ36046 SDF2L1 22q11.22 stromal cell-derived factor 2-like 1 LOC388865 22 similar to RIKEN cDNA 2610318N02 PPIL2 22q11.22 peptidylprolyl isomerase (cyclophilin)-like 2 YPEL1 22q11.2 yippee-like 1 (Drosophila) MAPK1 22q11.2 mitogen-activated protein kinase 1 PPM1F 22q11.22 protein phosphatase 1F (PP2C domain containing) FLJ23185 22q11.22 hypothetical protein FLJ23185 TOP3B 22q11 topoisomerase (DNA) III beta LOC391306 22 similar to Hypothetical protein DJ1198H6.2 IGLVI-70 22q11.2 immunoglobulin lambda variable (I)-70 IGLV4-69 22q11.2 immunoglobulin lambda variable 4-69 IGLVI-68 22q11.2 immunoglobulin lambda variable (I)-68 IGLV10-67 22q11.2 immunoglobulin lambda variable 10-67 IGLVIV-66-1 22q11.2 immunoglobulin lambda variable (IV)-66-1 IGLVV-66 22q11.2 immunoglobulin lambda variable (V)-66 IGLVIV-65 22q11.2 immunoglobulin lambda variable (IV)-65
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 5169 - 454 - Harvey (2004)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivepancreas exocrine    
    Lymphoid/Immunespleen    
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines immature myeloid cell line KG-1
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region plying important roles in the formation of the catalytically active structure of the enzyme
  • C-terminal region important for the maintenance of the catalytically active conformation
  • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to murine Ppm1f
    homolog to C.elegans FEM2
    Homologene
    FAMILY PP2C family of ser/thr protein phosphatases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • negative regulator of cell stress responses
  • dephosphorylates and deactivates CAMKII, CAMKIV and CAMKI
  • mediates caspase-dependent apoptosis when it is overexpressed maybe through a signaling pathway involving Bcl-XL and caspase-9
  • can interact with Rho guanine nucleotide exchange factors and block the effect of p21-activated kinase 1 (PAK1)
  • can regulate the activity of CAMK2A (dephosphorylates the critical autophosphorylation site of CAMK2A) and may play a key role in the regulation of the kinase intracellularly
  • CELLULAR PROCESS cell life, cell death/apoptosis
    protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component could form an heterotrimeric complex with PPM1E and PAK1
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binding two Mg2+ or Mn2+ ions
    protein interacting with Rho guanine nucleotide exchange factors
    cell & other
    REGULATION
    repressed by HIV-1 Tat in immature dendritic cells, allowing the expansion of HIV-1 infection
    Other Ca2+/Calmodulin dependent activity
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS