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FLASH GENE
Symbol PPM1E contributors: - updated : 10-10-2006
HGNC name protein phosphatase 1E (PP2C domain containing)
HGNC id 19322
Location 17q23.2      Physical location : 56.833.231 - 57.062.532
Synonym name
  • CAMKP-related protein
  • partner of PIX 1
  • protein phosphatase 2C
  • calmodulin-dependent protein kinase phosphatase N
  • Synonym symbol(s) KIAA1072, POPX1, PP2CH , CAMKPN,
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 229.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ZNF161 17q23.3 zinc finger protein 161 SFRS1 17q21.3-q22 splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) Dlc2 17q23.2 dynein light chain 2 OR4D1 17q24.2 olfactory receptor, family 4, subfamily D, member 1 HSHPX5 17q23.2 HPX-5 LOC124538 17q23.2 similar to Olfactory receptor 4D2 EPX 17q24-q25 eosinophil peroxidase FLJ20345 17q23.2 hypothetical protein FLJ20345 LPO 17q23.1 lactoperoxidase MPO 17q22-q23.1 myeloperoxidase BZRAP1 17q22-q23 benzodiazapine receptor (peripheral) associated protein 1 SUPT4H1 17q21-q23 suppressor of Ty 4 homolog 1 (S. cerevisiae) FLJ20315 17q23.2 hypothetical protein FLJ20315 FLJ40311 17q23.2 hypothetical protein FLJ40311 MTMR4 1721.1-q23 myotubularin related protein 4 PNUTL2 17q22-q23 peanut-like 2 (Drosophila) FLJ40121 17q23.2 hypothetical protein FLJ40121 TEX14 17q22-q23 testis expressed sequence 14 RAD51C 17q22-q23 RAD51 homolog C (S. cerevisiae) PPM1E 17q23.2 protein phosphatase 1E (PP2C domain containing) TRIM37 17q22-q23 tripartite motif-containing 37 LOC348235 17q23.2 hypothetical protein LOC348235 FLJ11029 17q23.2 hypothetical protein FLJ11029 FLJ10587 17q23.2 hypothetical protein FLJ10587 FLJ37451 17q23.2 hypothetical protein FLJ37451 LOC388403 17 similar to Yippee-like protein 2 (DiGeorge syndrome-related protein FKSG4) DHX40 17q23.2 DEAH (Asp-Glu-Ala-His) box polypeptide 40
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreasislet of Langerhans   
    Nervousbraindiencephalonamygdala highly
     nerve   highly
    Reproductivemale systemtestis  highly
    Urinarykidney    
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one phosphatase 2C motif
  • one phosphatase domain
  • a cluster of glutamate residues and a cluster of proline residues
  • mono polymer heteromer , trimer
    HOMOLOGY
    intraspecies homolog to CAMKP
    Homologene
    FAMILY PP2C family of Ser/Thr protein phosphatases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • blocking the effects of PAK, and thus inhibiting actin stress fiber breakdown and morphological changes driven by cell division cycle 42
  • regulating the phosphorylation level of GAPDH in the CaMKP-GAPDH complex by dephosphorylating and deactivating CaMKs that are responsible for the phosphorylation of GAPDH
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • could form an heterotrimeric complex with PPM1F and PAK1
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    manganese (Mn2+)
    protein interacting with PIX
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS