| basic FUNCTION
| contributing to growth inhibitory pathways activated in response to DNA damage in a TP53-dependant manner |
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phosphatase acting as a direct negative regulator of NF-Kappa B signaling  |
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may be a general regulator of apoptosis (loss of WIP1 sensitizes cell to stress- and DNA damage-induced apoptosis) |
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directly dephosphorylating gamma-H2AFX to silence the checkpoint and restore chromatin structure |
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important mammalian phosphatase for gamma-H2AFX with a role in the tumor surveillance network |
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may suppress NER (Nucleotide excision repair) kinetics by dephosphorylating and inactivating XPA and XPC and other NER proteins and regulators after UV-induced DNA damage is repaired |
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can act as an oncogene largely by turning off DNA damage checkpoint responses |
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can provide ample time for wild type TP53-containing cells to prepare entry into mitosis and avoid encountering mitotic catastrophe |
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may play important roles in cell/tissue homeostasis maintained by wild type TP53 under normal conditions, enhancing our understanding of how p53 makes cell-fate decisions |
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stress responsive PP2C phosphatase that plays a key role in stress signaling |
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functions to abrogate cell cycle checkpoints and inhibit senescence, apoptosis, DNA repair, and the production of inflammatory cytokines |
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play an important role in several physiological processes including adult neurogenesis and organismal aging |
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positive modulator of the HH signaling |
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role in modulating the activity of GLI1 and in sustaining cancer cell growth and cancer stem cell self-renewal induced by activation of the HH pathway |
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plays a key role in the transcriptional regulation of heterochromatin-associated DNA sequences |
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plays an important role in the regulation of global heterochromatin silencing and thus is critical in maintaining genome integrity |
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unrecognized function of PPM1D as an intrinsic negative regulator for neutrophil proinflammatory cytokine production and migration through multiple signal pathways |
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controls DKK3-dependent inhibition of neuronal differentiation during aging, suggesting that regulating PPM1D levels could prevent certain aspects of functional decline of the aging brain |
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plays a critical role in maintaining antigen-independent B-cell development in the bone marrow and preventing an aging-related decline in B-cell development |
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PPM1D-ULK1 axis plays a pivotal role in genotoxic stress-induced autophagy |
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type 2C phosphatase that functions as a negative regulator of cellular stress-response pathways by mediating a feedback loop of MAPK14-TP53 signaling, thereby contributing to growth inhibition and suppression of stress-induced apoptosis |
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PP2C serine-threonine phosphatase, that is an important regulator of stress response |
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controls a number of critical cellular functions: proliferation, cell cycle arrest, senescence and programmed cell death, apoptosis or autophagy |
