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FLASH GENE
Symbol PPM1B contributors: mct - updated : 30-05-2015
HGNC name protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform
HGNC id 9276
Location 2p21      Physical location : 44.395.999 - 44.461.741
Synonym name
  • protein phosphatase 2C beta isoform
  • protein phosphatase 2C-like protein
    • Synonym symbol(s) PP2CB, PP2CBETA, PPC2BETAX , PPC2betaX
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 65.74 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text a number of isoforms such as beta-x produced by alternative spilcing (they only differe in their C terminus)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 2636 52.6 479 - 1998 9684878
  • beta1
    • 6 - 3850 - 387 - 1998 9684878
    5 - 1776 - 192 - 1998 9684878
    4 - 1497 - 327 - 1998 9684878
    6 - 3056 - 380 - 1998 9684878
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
    Hearing/Equilibriumearinnercochlea highly
    Lymphoid/Immunelymph node   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , monomer
    HOMOLOGY
    interspecies homolog to murine Ppm1b
    homolog to C.elegans f25d1.1
    Homologene
    FAMILY PP2C family of Ser/Thr protein phosphatases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • localized in the nucleus of mature 3T3-L1 adipocytes where it can bind to PPARG (PMId: 23320500)
    • basic FUNCTION
  • dephosphorylating cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control
  • PPM1A and PPM1B play an important role in the termination of TNF-mediated NF-kappaB activation through dephosphorylating and inactivating IKBKB
  • likely has an indirect role in regulating KLF1 turnover via its zinc finger domain
  • plays a multilayered role in regulating the availability and optimal activity of the KLF1 protein in erythroid cells
  • N-myristoylation of PPM1A and PPM1B plays a key role in recognition of their physiological substrates in cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
    two magnesium Mg2+ or two manganese Mn2+
    protein
  • association with the IKK complex led to the dephosphorylation of IKKbeta and decreased its kinase activity
  • PPM1A and PPM1B, are IKBKB phosphatases
  • interacts with KLF1 via its PEST1 sequence
  • previously unrecognized role for PPM1B in the negative regulation of antiviral response by acting as a TBK1 phosphatase
  • novel selective modulator of PPARG activity
  • PPM1B can dephosphorylate the PAX2 activation domain and displace the adaptor protein PAXIP1, thus inhibiting H3K4 methylation and gene activation
    • cell & other
    REGULATION
    Other N-myristoylated and this modification is essential for its ability to dephosphorylate the alpha subunit of AMPK in cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS