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Symbol PPIL1 contributors: mct - updated : 06-10-2006
HGNC name peptidylprolyl isomerase (cyclophilin)-like 1
HGNC id 9260
Location 6p21.1      Physical location : 36.822.605 - 36.842.800
Synonym name
  • cyclophilin-related gene 1
  • rotamase
  • Synonym symbol(s) CGI-124, CYPL1, MGC678, PPIase, hCyPX
    EC.number 5.2.1.8
    DNA
    TYPE functioning gene
    STRUCTURE 20.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map pter - D6S1875 - D6S291 /PPIL1 - D6S1832 - cen
    Authors Mann (98)
    Text see OTOF
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
     stomach   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PPIase cyclophilin-type domain
  • HOMOLOGY
    Homologene
    FAMILY
  • immunophilin class M family
  • cyclophilin family of peptidylprolyl isomerases (PPIases)
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • peptidylprolyl isomerase (cyclophilin)-like 1, cellular target of cyclosporin A
  • could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
  • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with SNW1 (recruits PPIL1 into the spliceosome by a region other than the peptidylprolyl isomerase active site)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS