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FLASH GENE
Symbol PPIH contributors: npt/ - updated : 26-07-2005
HGNC name peptidyl prolyl isomerase H (cyclophilin H)
HGNC id 14651
Location 1p34.1      Physical location : 43.124.047 - 43.142.428
Synonym name
  • USA-CyP SnuCyp-20
  • cyclophilin H
  • U-snRNP-associated cyclophilin SunCyp-20
  • small nuclear ribonucleoprotein particle-specific cyclophilin H
  • rotamase H
  • peptidyl-prolyl cis-trans isomerase H
  • PPIase h
  • Synonym symbol(s) USA-CYP, CYP-20, SnuCyp-20, CYPH, MGC5016
    EC.number 5.2.1.8
    DNA
    TYPE functioning gene
    STRUCTURE 18.38 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391031 1 similar to Heterogeneous nuclear ribonucleoprotein F (hnRNP F) GUCA2B 1p35-p34 guanylate cyclase activator 2B (uroguanylin) GUCA2A 1p35-p34 guanylate cyclase activator 2A (guanylin) KIAA1041 1p35-p32 guanylate cyclase activator 2A (guanylin) MGC47816 1p34.1 hypothetical protein MGC47816 ZMYND12 1p34.1 zinc finger, MYND domain containing 12 FLJ11838 1p34.1 hypothetical protein FLJ11838 FLJ20972 1p34.1 hypothetical protein FLJ20972 TMSL1 1 thymosin-like 1 PPIH 1p34.1 peptidyl prolyl isomerase H (cyclophilin H) NSEP1 1p34 nuclease sensitive element binding protein 1 CLDN19 1p33-34.2 claudin 19 LEPRE1 1p34.1 leucine proline-enriched proteoglycan (leprecan) 1 MGC955 1p34.1 hypothetical protein MGC955 LOC388624 1 LOC388624 ERMAP 1p34.1 erythroblast membrane-associated protein LOC51058 1p34.1 hypothetical protein LOC51058 LOC391032 1 similar to EVIN1; expressed in activated T/LAK lymphocytes LOC391033 1 similar to Makorin 1 LOC343515 1p34.1 similar to ATPase, H+ transporting, lysosomal 31kD, V1 subunit E isoform 1; V-ATPase, subunit E; H(+)-transporting two-sector ATPase, 31kDa subunit; H+-transporting ATP synthase chain E, vacuolar; vacuolar proton pump, 31-kd subunit SLC2A1 1p35-p31.3 solute carrier family 2 (facilitated glucose transporter), member 1 EBNA1BP2 1p35-p33 EBNA1 binding protein 2 FLJ32000 1p34.1 hypothetical protein FLJ32000 LOC256339 1p34.1 similar to ENSANGP00000010412 MGC17299 1p34.1 hypothetical protein MGC17299 MGC52423 1p34.1 hypothetical protein MGC52423 TIE 1p34 tyrosine kinase with immunoglobulin and epidermal growth factor homology domains CDC20 9q13-q21 CDC20 cell division cycle 20 homolog (S. cerevisiae) MPL 1p34 myeloproliferative leukemia virus oncogene ELOVL1 1p34.1 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 MED8 1p34.1 mediator of RNA polymerase II transcription, subunit 8 homolog (yeast) LOC388625 1 similar to FLJ00408 protein HT036 1p34.1 hypothetical protein HT036 PTPRF 1p34 protein tyrosine phosphatase, receptor type, F
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 813 19.1 177 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • cyclophilin domain
  • conjugated HemoP
    mono polymer heteromer , monomer , polymer
    HOMOLOGY
    interspecies homolog to C.elegans Cyp-11
    intraspecies homolog to PPIA
    Homologene
    FAMILY
  • cyclophilin family
  • CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • cistransisomerization of peptidyl-prolyl bonds
  • CELLULAR PROCESS nucleotide, RNA splicing
    protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • spliceosomal 25S (U4/U6,U5) tri-snRNP complex
  • INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH
  • protein
  • U4/U6 specific,60kDa (PRP4)
  • flavoprotein P450 oxidoreductase (POR)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS