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FLASH GENE
Symbol PPIC contributors: np/ - updated : 17-03-2008
HGNC name peptidylprolyl isomerase C (cyclophilin C)
HGNC id 9256
Location 5q23.2      Physical location : 122.359.079 - 122.372.425
Synonym name
  • rotamase C
  • cyclophilin C
  • parvulin
  • Synonym symbol(s) CYPC, PPIase C, MGC3673
    EC.number 5.2.1.8
    DNA
    TYPE functioning gene
    STRUCTURE 13.35 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ33977 5q23.1 hypothetical protein FLJ33977 PTMAP2 5 prothymosin, alpha pseudogene 2 (gene sequence 32) LOC391822 5 similar to chromosome 20 open reading frame 147 DMXL1 5q22 Dmx-like 1 GG2-1 LOC389318 5 LOC389318 HSD17B4 5q2 hydroxysteroid (17-beta) dehydrogenase 4 LOC391823 5 similar to 60S RIBOSOMAL PROTEIN L21 LOC340069 5q23.2 hypothetical protein LOC340069 LOC391824 5 similar to tubulin, alpha 6; tubulin alpha 6 LOC348958 5q23.2 mitochondrial ribosomal protein L10 pseudogene LOC51334 5q23.2 mesenchymal stem cell protein DSC54 LOC391825 5 similar to 60S ribosomal protein L23a LOC256233 5q23.2 similar to ribosomal protein L18; 60S ribosomal protein L18 MTF  mitochondrial ferritin FLJ25286 5q23.2 hypothetical protein FLJ25286 LOX 5q23.3-q31.2 lysyl oxidase LOC133923 5q23.2 similar to RIKEN cDNA 4933409D10 LOC153441 5q23.2 similar to RIKEN cDNA 4933409D10 SNCAIP 5q23.1-q23.3 synuclein, alpha interacting protein (synphilin) SNX2 5q23 sorting nexin 2 SNX24 5q23.2 sorting nexing 24 PPIC 5q23.2 peptidylprolyl isomerase C (cyclophilin C) PRDM6 5q21-q23 PR domain containing 6 LOC391826 5 similar to Ubiquitin-like protein SMT3C precursor (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein UBL1) (Ubiquitin-related protein SUMO-1) (GAP modifying protein 1) (GMP1) (Sentrin) FLJ36090 5q23.2 hypothetical protein FLJ36090 CSNK1G3 5q23 casein kinase 1, gamma 3 LOC391827 5 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) KIAA1281 5q23.2 KIAA1281 protein LOC391828 5 similar to ribosomal protein L28 LOC391829 5 similar to High mobility group protein 1-like 10 (HMG-1L10) LOC389319 5 LOC389319 NS3TP2 5q23.3 HCV NS3-transactivated protein 2 ALDH7A1 5q31 aldehyde dehydrogenase 7 family, member A1 PHAX 5q23.3 likely ortholog of mouse phosphorylated adaptor for RNA export LOC133609 5q23.3 similar to 60S acidic ribosomal protein P1 LOC389320 5 hypothetical gene supported by AK131015 LOC285008 5q23.3 hypothetical gene supported by BC028282; BC028282; BC028282 LMNB1 5q23.3-q31.1 lamin B1 LOC389321 5 LOC389321 MGC48332 5q23.3 hypothetical protein MGC48332
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1241 - 212 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a core central region
  • the PPI and CSA binding domain flanked by variable N and C terminal domains
  • conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • immunophilin class M family
  • cyclophilin-type PPIase family
  • CATEGORY chaperone/stress , enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • immunophilin action
  • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with calcineurin leading to immunosuppression
  • INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH
    protein
  • flavoprotein P450 oxidoreductase (POR)
  • cell & other
    REGULATION
    inhibited by cyclosporin A
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS