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FLASH GENE
Symbol PPIC contributors: np/ - updated : 17-03-2008
HGNC name peptidylprolyl isomerase C (cyclophilin C)
HGNC id 9256
Location 5q23.2      Physical location : 122.359.079 - 122.372.425
Synonym name
  • rotamase C
  • cyclophilin C
  • parvulin
  • Synonym symbol(s) CYPC, PPIase C, MGC3673
    EC.number 5.2.1.8
    DNA
    TYPE functioning gene
    STRUCTURE 13.35 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1241 - 212 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a core central region
  • the PPI and CSA binding domain flanked by variable N and C terminal domains
  • conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • immunophilin class M family
  • cyclophilin-type PPIase family
  • CATEGORY chaperone/stress , enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • immunophilin action
  • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with calcineurin leading to immunosuppression
  • INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH
    protein
  • flavoprotein P450 oxidoreductase (POR)
  • cell & other
    REGULATION
    inhibited by cyclosporin A
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS