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FLASH GENE
Symbol PPFIBP1 contributors: SGE/npt - updated : 11-06-2010
HGNC name PTPRF interacting protein, binding protein 1 (liprin beta 1)
HGNC id 9249
Location 12p11.22      Physical location : 27.677.044 - 27.848.496
Synonym name
  • polypeptide-interacting protein-binding protein 1
  • liprin related protein
  • protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding 1
  • Synonym symbol(s) KIAA1230, L2, SGT2, hSGT2, hSgt2p
    DNA
    TYPE functioning gene
    STRUCTURE 171.45 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    FLJ36004 12p12.1 hypothetical protein FLJ36004 LOC283347 12p12.1 similar to thymine-DNA glycosylase C12orf2 12p12.3 chromosome 12 open reading frame 2 BHLHB3 12p12.1-p11.23 basic helix-loop-helix domain containing, class B, 3 LOC387848 12 LOC387848 SSPN 12p11.2 sarcospan (Kras oncogene-associated gene) ITPR2 12p11 inositol 1,4,5-triphosphate receptor, type 2 LOC341370 12p12.1 similar to Dag1-prov protein FLJ10637 12p12.1 hypothetical protein FLJ10637 DKFZP564O1863 TM7SF3 12q11.2-q12 transmembrane 7 superfamily member 3 SURB7 12p12.3 SRB7 suppressor of RNA polymerase B homolog (yeast) LOC341371 12p12.1 hypothetical LOC341371 STK38L 12p12.3-p11.22 serine/threonine kinase 38 like ARNTL2 12p11.23-p11.22 aryl hydrocarbon receptor nuclear translocator-like 2 LOC341346 12p12.1 similar to hypothetical protein PPFIBP1 12q14.3 PTPRF interacting protein, binding protein 1 (liprin beta 1) LOC387849 12 similar to RIKEN cDNA 2210417D09 MRPS35 12p11 mitochondrial ribosomal protein S35 KIAA1340 12p12.1 KIAA1340 protein PTHLH 12p11.2 parathyroid hormone-like hormone FLJ11088 12p11.23 GGA binding partner FLJ10462 12p11.23 hypothetical protein FLJ10462 PTX1 12p11.23 PTX1 protein OVCH1 12p11.23 ovochymase 1 LOC387618 12 hypothetical gene supported by AK125140; NM_194311 ARG99 12p11.23 ARG99 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 6076 - 1005 - Serra-Pagès (1998)
  • isoform 1
  • 6 - 971 - 170 - Serra-Pagès (1998)
  • isoform 2
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three SAM domains
  • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to C.elegans celiprin beta
    homolog to murine Ppfibp1 (90.1pc)
    homolog to rattus Ppfibp1 (89.7pc)
    intraspecies paralog to liprin beta 2
    Homologene
    FAMILY
  • LAR protein-tyrosine phosphatase-interacting protein (liprin) family
  • liprin family
  • liprin beta subfamily
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may regulate the disassembly of focal adhesions (Serra-Pages 1998)
  • playing an important role in the maintenance of lymphatic vessel integrity (Normen 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • may be multivalent protein that forms complex structures and acts as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatase (Serra-Pagès 1998)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to alpha liprins PPFIAs through the LH domain
  • interacting with S100A4 (inhibiting its phosphorylation by PKC and CK2 in a calcium-dependent mode)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS