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Symbol PPEF2 contributors: np/ - updated : 26-03-2008
HGNC name protein phosphatase, EF hand calcium-binding domain 2
HGNC id 9244
Location 4q21.1      Physical location : 76.781.027 - 76.823.681
Synonym name
  • protein phosphatase 7, catalytic subunit, beta isozyme
  • serine/threonine-protein phosphatase with EF-hands 2
  • Synonym symbol(s) PPEF-2, PPE2, PPP7CB
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 42.65 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3430 - 753 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeretina    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualrod photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two EF hand calcium binding domain
  • one IQ domain
  • PP2A homologues catalytic domain
  • HOMOLOGY
    interspecies homolog to murine Ppef2
    Homologene
    FAMILY
  • PPP phosphatase family
  • CATEGORY enzyme , signaling , receptor membrane phosphatase
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in phototransduction (may dephosphorylate photoactivated rhodopsin)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Mg2+
  • protein
    cell & other
    REGULATION
    activated by calcium
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS