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FLASH GENE
Symbol PPBP contributors: mct/npt - updated : 08-04-2009
HGNC name pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
HGNC id 9240
Location 4q13.3      Physical location : 74.852.155 - 74.853.907
Synonym name
  • platelet basic protein
  • small-inducible cytokine B7
  • thrombocidin
  • leukocyte-derived growth factor
  • macrophage-derived growth factor
  • connective tissue-activating peptide III
  • beta-thromboglobulin
  • neutrophil-activating peptide 2
  • Synonym symbol(s) PPBPl1, CTAP3, PBP, PLBP, TGB, LDGF, MDGF, TGB1, CXCL7, NAP-2, SCYB7, THBGB, b-TG1, LA-PF4, THBGB1, Beta-TG, CTAPIII, NAP-2-L1, LDGF
    DNA
    TYPE functioning gene
    STRUCTURE 1.14 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif
    MAPPING cloned Y linked N status confirmed
    Map cen - IL8 - CXCL1 /PPBP /PF4 - CXCL5 /CXCL6 - CXCL2 /CXCL3 - CXCL11 - CXCL10 - CXCL9 - qter
    Authors O'Donovan (99)
    Text see IMC2@
    Physical map
    FLJ38991 4q21.1 hypothetical protein FLJ38991 ANKRD17 4q13.3 ankyrin repeat domain 17 HMGA1L2 4q21.1 high mobility group AT-hook 1-like 2 ALB 4q11-q13 albumin AFP 4q11-q13 alpha-fetoprotein AFM 4q11-q13 afamin RASSF6 4q21.21 Ras association (RalGDS/AF-6) domain family 6 IL8 4q13-q21 interleukin 8 CXCL6 4q21 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) PF4V1 4q13-q21 platelet factor 4 variant 1 CXCL1 4q21 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) CXCL1P 4q21.21 chemokine (C-X-C motif) ligand 1 pseudogene PF4 4q13-q21 platelet factor 4 (chemokine (C-X-C motif) ligand 4) PPBP 4q12-q13 pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) CXCL5 4q13-q21 chemokine (C-X-C motif) ligand 5 CXCL3 4q21 chemokine (C-X-C motif) ligand 3 SPBPBP 4q21.21 DNA-binding protein amplifying expression of surfactant protein B CXCL2 4q21 chemokine (C-X-C motif) ligand 2 LOC255324 4q21.21 similar to ALGV3072 EREG 4q25-q26 epiregulin AREG 4q13-q21 amphiregulin (schwannoma-derived growth factor) BTC 4q13-q21 betacellulin
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 715 10.27 128 - Smith (2006)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Reproductivefemale systemplacenta   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmegakaryocyte
    Blood/Hematopoieticplatelet
    cell lineage
    cell lines
    fluid/secretion plasma
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • intercrine alpha family (small cytokine CXC)
  • CATEGORY secretory , signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • stimulating DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, synthesis of hyaluronic acid and sulfated glycosaminoglycan and the formation and secretion of plasminogen activator by human synovial cells
  • being a potent chemoattractant and activator for neutrophils
  • stimulates the priming of osteoclast progenitors for differentiation into osteoclasts (Nakao 2009)
  • has the potential to induce inflammatory responses within the atherosclerotic plaque (Smith 2006)
  • may be playing a role to limit platelet-activating factor -dependent vascular tissue damage by preventing degranulation of neutrophils without affecting their migration into the inflamed tissue (Schwartzkopff 2002)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    text
  • glucose transporter
  • blood clotting
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IGF2 (has the ability to strongly stimulate osteoclastogenesis by regulating PPBP expression in stromal cells and SDF1 expression in osteoblastic cells) (Nakao 2009)
  • with PPBP may promote the formation of giant osteoclasts (Nakao 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in acute coronary syndromes (Smith 2006)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS