Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PPAT contributors: - updated : 04-01-2007
HGNC name phosphoribosyl pyrophosphate amidotransferase
HGNC id 9238
Location 4q12      Physical location : 57.259.530 - 57.301.845
Synonym name
  • phosphoribosylamine synthetase
  • glutamine phosphoribosylpyrophosphate amidotransferase
  • Synonym symbol(s) ATASE, GPAT
    EC.number 2.4.2.14
    DNA
    TYPE functioning gene
    STRUCTURE 42.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map 3' - PAICS - 5' - 5' - PPAT - 3'
    Authors Brayton (94)
    Physical map
    KDR 4q12 kinase insert domain receptor (a type III receptor tyrosine kinase) FLJ13352 4q12 hypothetical protein FLJ13352 TPARL 4q12 TPA regulated locus CLOCK 4q12 clock homolog (mouse) GCPHLP 4q12 likely ortholog of mouse germ cell-specific phosphoducin-like protein Mgcphlp NMU 4q12 neuromedin U SEC3 FLJ13621 4q12 hypothetical protein FLJ13621 KIAA0635 4q12-q13.3 hypothetical protein FLJ13621 KIAA1211 4q12 KIAA1211 protein MRPL22P1 4q12 KIAA1211 protein NRPS998 4q12 2-aminoadipic 6-semialdehyde dehydrogenase PPAT 4q12 phosphoribosyl pyrophosphate amidotransferase PAICS 4q12 phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase SRP72 1q32 signal recognition particle 72kDa LOC132946 4q12 similar to MGC69138 protein LOC391654 4 LOC391654 GLDCP 4q12 glycine dehydrogenase (decarboxylase) pseudogene HOP 4q11-q12 homeodomain-only protein LOC391655 4 similar to 60S ribosomal protein L17 (L23) LOC285453 4q12 similar to APACD protein SPINK2 4q12 serine protease inhibitor, Kazal type, 2 (acrosin-trypsin inhibitor) REST 4q12 RE1-silencing transcription factor MGC3232 POLR2B 4q12 polymerase (RNA) II (DNA directed) polypeptide B, 140kDa IGFBP7 4q12 insulin-like growth factor binding protein 7 LOC255130 4q12 hypothetical LOC255130
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a type-2 glutamine amidotransferase domain
  • four consensus phosphorylation sites for cAMP-dependent protein kinase
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY purine/pyrimidine phosphoribosyltransferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION phosphoribosyl pyrophosphate amidotransferase, catalyzing the first step of the de novo purine biosynthesis
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    nucleotide biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • binds 1 magnesium ion per subunit
  • binds 1 4fe-4s cluster per subunit
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS