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FLASH GENE
Symbol PPAT contributors: - updated : 04-01-2007
HGNC name phosphoribosyl pyrophosphate amidotransferase
HGNC id 9238
Location 4q12      Physical location : 57.259.530 - 57.301.845
Synonym name
  • phosphoribosylamine synthetase
  • glutamine phosphoribosylpyrophosphate amidotransferase
  • Synonym symbol(s) ATASE, GPAT
    EC.number 2.4.2.14
    DNA
    TYPE functioning gene
    STRUCTURE 42.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map 3' - PAICS - 5' - 5' - PPAT - 3'
    Authors Brayton (94)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a type-2 glutamine amidotransferase domain
  • four consensus phosphorylation sites for cAMP-dependent protein kinase
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY purine/pyrimidine phosphoribosyltransferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION phosphoribosyl pyrophosphate amidotransferase, catalyzing the first step of the de novo purine biosynthesis
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    nucleotide biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • binds 1 magnesium ion per subunit
  • binds 1 4fe-4s cluster per subunit
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS