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FLASH GENE
Symbol POU2F3 contributors: mct/ - updated : 07-02-2007
HGNC name POU class 2 homeobox 3
HGNC id 19864
Location 11q23.3      Physical location : 120.110.950 - 120.190.653
Synonym name
  • POU domain, class 2, transcription factor 3
  • epidermal octamer binding factor 1
  • POU transcription factor,(Skn-1a/Epoc-1/OCT-11)
  • transcription factor PLA-1
  • Synonym symbol(s) OCT11, PLA-1, EPOC-1, SKN-1A, MGC126698
    DNA
    TYPE functioning gene
    STRUCTURE 79.70 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D11S924 - D11S1111 - D11S2063 - PVRL1 - D11S1299 - D11S2087 - D11S4132 - D11S994 - TRIM29 - D11S2088 - POU2F3 - ARHGEF12 - D11S4343 - D11S925 - qter
    Physical map
    CBL 11q23.3 Cas-Br-M (murine) ecotropic retroviral transforming sequence MCAM 11q23.3 melanoma cell adhesion molecule RNF26 11q23 ring finger protein 26 C1QTNF5 11q23.3 C1q and tumor necrosis factor related protein 5 MFRP 11q23 membrane frizzled-related protein USP2 11q23.3 ubiquitin specific protease 2 LOC94105 11q22.3-q23 Thy-1 co-transcribed THY1 11q23.3 Thy-1 cell surface antigen LOC387813 11 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 PVRL1 11q23-q24 poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin) LOC390255 11 similar to HLA-B-associated transcript 1A; nuclear RNA helicase Bat1 LOC387814 11 LOC387814 TRIM29 11q22-q23 tripartite motif-containing 29 LOC219908 11q23.3 hypothetical LOC219908 NS5ATP13TP2 11q23.3 NS5ATP13TP2 protein POU2F3 11q23.3 POU domain, class 2, transcription factor 3 MGC17839 11q23.3 hypothetical protein MGC17839 ARHGEF12 11q23.3 Rho guanine nucleotide exchange factor (GEF) 12 GRIK4 11q23 glutamate receptor, ionotropic, kainate 4 MGC10233 11q23.3 hypothetical protein MGC10233 TECTA 11q22-q24 tectorin alpha
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2965 - 436 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus    
     intestinelarge intestinecolon  
     intestinesmall intestine   
    Respiratoryrespiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermis  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • POU specific and POU homeo (helix-turn-helix) domains
  • HOMOLOGY
    Homologene
    FAMILY
  • POU transcription factor family
  • class 2 subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulating the differentiation of epidermal keratinocytes during normal development and wound healing
  • also involved in the differentiation dependent regulation of human papillomavirus (HPV18)
  • may serve a regulatory function with respect to epidermal development
  • regulated the expression of a number of genes
  • such as SPRR2A or placental lactogen
  • likely to play a major role in the fine-tuning of keratinocyte terminal differentiation
  • plays a major role in epidermal development as it can inhibit KRT14 expression
  • able to effectively inhibit deltaNp63alpha transactivation of the KRT14 promoter
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text epidermal differentiation; transcription activating factor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • antagonistic roles of POU2F3 and deltaNp63, probably through competition for overlapping binding sites or through an indirect interaction
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by aberrant promoter methylation and silencing in cervical cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS