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FLASH GENE
Symbol POU2F2 contributors: mct - updated : 19-11-2016
HGNC name POU domain, class 2, transcription factor 2
HGNC id 9213
Location 19q13.31      Physical location : 42.592.672 - 42.636.630
Synonym name octamer-binding transcription factor 2
Synonym symbol(s) OCT2, OTF2, Oct-2
DNA
TYPE functioning gene
STRUCTURE 46.36 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
CEACAM4 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 4 CEACAM7 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 7 CEACAM5 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 5 CEACAM6 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) CEACAM3 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 3 LOC388544 19 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) MGC42718 19q13.31 hypothetical protein MGC42718 DMRTC2 19q13.31 DMRT-like family C2 RPS19 19q13.2 ribosomal protein S19 CD79A 19q13.2-q13.3 CD79A antigen (immunoglobulin-associated alpha) ARHGEF1 19q13,13 Rho guanine nucleotide exchange factor (GEF) 1 LOC390937 19 similar to Erf RABAC1 19q13.13-q13.2 Rab acceptor 1 (prenylated) ATP1A3 19q13.2 ATPase, Na+/K+ transporting, alpha 3 polypeptide GRIK5 19q13.2 glutamate receptor, ionotropic, kainate 5 FLJ22059 19q13.31 hypothetical protein FLJ22059 POU2F2 19q13.31 POU domain, class 2, transcription factor 2 DEDD2 19q13.31 POU domain, class 2, transcription factor 2 KIAA1951 GSK3A 19q13.2 glycogen synthase kinase 3 alpha ERF 19q13.1 Ets2 repressor factor CIC 19q13.2 capicua homolog (Drosophila) PAFAH1B3 19q13.1 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa MGC70924 19q13.31 hypothetical LOC284338 FLJ90805 19q13.31 hypothetical protein FLJ90805 EGFL4 19q12 EGF-like-domain, multiple 4 SBP1 19q13.31 HBV pre-s2 binding protein 1 LOC84518 19q13.31 protein related with psoriasis LIPE 19q13.1-q13.2 lipase, hormone-sensitive
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 splicing 6952 - 479 - 1999 1104332
OCT2A
14 splicing 6904 - 463 - 1999 1104332
  • OCT2B
  • - splicing 1703 - 467 - 1999 1104332
    14 - 6768 - 400 - 1999 1104332
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     spleen   highly
     thymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • DNA binding protein, with POU specific and POU homeo (helix-turn-helix) domains
  • potential leucine zipper domain
  • HOMOLOGY
    interspecies homolog to murine Pou2f2
    homolog to C.elegans c30a5.7b
    Homologene
    FAMILY class II POU homeodomain family of transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in the control of the forebrain development and the cell-cell signaling process underlying the hypothalamic regulation of female puberty
  • playing a role in regulating transcription in a number of tissues in addition to activating immunoglobulin gene expression
  • playing an essential role during the terminal phase of B cell differentiation
  • with POU2F2, are B-cell associated transcription factors expressed in a subset of patients with acute myeloid leukemia (AML)
  • POU2AF1 together with POU2F1/POU2F2, binds to octamer sites in promoters and enhancers to activate transcription of immunoglobulin (Ig) genes
  • POU2F1 and GATA3/POU2F2 direct Th2 cytokine gene expression in a cooperative manner
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the octamer motif ATGCAAAT
    RNA
    small molecule
    protein
  • ZNF593
  • repressing the involucrin promoter activity in epithelial cells and in the presence of the silencer element(when overexpressed)
  • POU2AF1 is a B lymphocyte-specific transcription factor which coactivates POU2F1 and POU2F2 on B cell specific promoters
  • PDCD1LG2 expression is regulated by two different promoters that function in a lineage-specific manner, with the B-1-specific promoter being constitutively active as a result of POU2F1 and POU2F2 binding
  • a putative defect in POU2F1 and/or POU2F2, by affecting HMGA1 expression, may cause INSR dysfunction, leading to defects of the INSR signaling pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    expressed in systemic anaplastic large cell lymphomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS