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FLASH GENE
Symbol POU2F1 contributors: mct - updated : 04-02-2019
HGNC name POU class 2 homeobox 1
HGNC id 9212
Location 1q24.2      Physical location : 167.190.142 - 167.385.317
Synonym name
  • octamer-binding transcription factor 1
  • POU domain, class 2, transcription factor 1
  • Synonym symbol(s) OCT1, OTF1, NF-A1, FLJ42836
    DNA
    TYPE functioning gene
    STRUCTURE 206.52 kb     17 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LMX1A 1q22-q23 LIM homeobox transcription factor 1, alpha RXRG 1q22-q23 retinoid X receptor, gamma LOC284684 1q23.2 similar to cDNA sequence BC004853 LOC391125 1 similar to ribosomal protein S2; 40S ribosomal protein S2 MGST3 1q23 microsomal glutathione S-transferase 3 ALDH9A1 1q22-q23 aldehyde dehydrogenase 9 family, member A1 LOC54499 1q22-q25 putative membrane protein LOC391126 1 similar to 60S ribosomal protein L26 UMPK 1p34.1-p33 uridine monophosphate kinase LOC391127 1 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC149297 1q23.3 similar to RIKEN cDNA C030014K22 gene LOC284685 1q23.3 similar to Ewing sarcoma breakpoint region 1 isoform EWS LOC391128 1 similar to hypothetical protein 4831428F09 LOC116123 1q23.3 hypothetical protein BC014341 LOC391129 1 similar to ribosomal protein L4; 60S ribosomal protein L4; homologue of Xenopus ribosomal protein L1 POGK 1q23.2 pogo transposable element with KRAB domain STAF42 1q23.3 SPT3-associated factor 42 LOC388712 1 similar to dJ782G3.1 (LISCH7 (liver-specific BHLH-ZIP transcription factor)) FLJ14904 1q23.3 hypothetical protein FLJ14904 GPA33 1q23.2 glycoprotein A33 (transmembrane) LOC92235 1q22-q24 hypothetical cardiac/skeletal muscle-expressed ORF LOC391130 1 similar to ribosomal protein S17 POU2F1 1q22-q23 POU domain, class 2, transcription factor 1 CD3Z 1q22-q23 CD3Z antigen, zeta polypeptide (TiT3 complex) SRD5BP1 1q23-q25 steroid-5-beta-reductase, beta polypeptide pseudogene 1 CREG 1q24 cellular repressor of E1A-stimulated genes MGC21854 1q22-q24 hypothetical protein MGC21854 MPZL1 1q23.2 myelin protein zero-like 1 FLJ21047 1q23.3 hypothetical protein FLJ21047 SAC DKFZP564B167 1q24 DKFZP564B167 protein PC326 1q23.3 PC326 protein GCSH 16q24 glycine cleavage system protein H (aminomethyl carrier) GPR161 1q23.3 G protein-coupled receptor 161 MGC3794 1q23.2 putative MAPK activating protein RPL34P1 1q23-q24 ribosomal protein L34 pseudogene 1 LOC375035 1q23.3 hypothetical protein LOC375035 MGC12538 1q23.3 hypothetical protein MGC12538 TBX19 1q23-q24 T-box 19 LOC391131 1 similar to glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 XCL2 1q23-q25 chemokine (C motif) ligand 2 XCL1 1q23 chemokine (C motif) ligand 1 DPT 1q12-q23 dermatopontin MGC4473 1q23.3 hypothetical protein MGC4473 LOC391132 1 similar to ribosomal protein L29 ATP1B1 1q23.2-q23.3 ATPase, Na+/K+ transporting, beta 1 polypeptide NME7 1q24 non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) BLZF1 1q24-q25 basic leucine zipper nuclear factor 1 (JEM-1) LOC57821 1q24 hypothetical protein LOC57821 SLC19A2 1q23.2-q23.3 solute carrier family 19 (thiamine transporter), member 2 F5 1q23.2-q23.3 coagulation factor V (proaccelerin, labile factor)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 13905 - 766 expressed at a high level in the CD34+ hematopoetic progenitor cells 2018 30042821
  • OCT1L
  • 15 - 13716 - 703 - 2018 30042821
    16 - 14038 - 755 - 2018 30042821
    18 - 14342 - 741 - 2018 30042821
    17 - 14138 - 741 - 2018 30042821
    - - 1911 - 623 found in B cells, but not in hematopoetic progenitor cells 2018 30042821
  • is transcribed from the same promoter as Oct-1L
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Endocrineadrenal gland   highly
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Nervousbraindiencephalonepithalamushabenula 
     brainhindbrainmedulla oblongataarea postrema 
    cells
    SystemCellPubmedSpeciesStageRna symbol
     granular cell
    Nervousmammilary cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • POU specific and POU homeo (helix-turn-helix) domains
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Pou2f1 (93.8pc)
    homolog to rattus Pou2f1 (95.3pc)
    Homologene
    FAMILY
  • POU transcription factor family, class 2 subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • POU2F1 colocalizes with lamin B1 at the spindle poles and midbody
  • basic FUNCTION
  • transcription factor for small nuclear RNA and histone H2B genes
  • involved in the transcriptional repression of the gonadotropin-releasing hormone receptor gene(GNRHR)
  • repressing with its POU domain, the expression of E-selectin, vascular cell adhesion molecule (VCAM-1), two cytokine-inducible, NF-kappaB-dependent endothelial-leukocyte adhesion molecules that participate in the leukocyte recruitment phase of the inflammatory response
  • transactivating PTTG1 (Zhou 2008)
  • downstream effector of Notch signaling during radial glia formation (Kiyota 2008)
  • may have regulatory functions in prostate development and cancer progression (Jariwala 2009)
  • is phosphorylated in response to oxidative and genotoxic stress and is essential for a normal post-stress transcriptional response (Kang 2009)
  • POU2AF1 together with POU2F1/POU5F1, binds to octamer sites in promoters and enhancers to activate transcription of immunoglobulin (Ig) genes
  • a putative defect in POU2F1 and/or POU2F2, by affecting HMGA1 expression, may cause INSR dysfunction, leading to defects of the INSR signaling pathway
  • new role for POU2F1 in mesenchymal stem cells (hMSCs) aging
  • POU2F1 and POU2AF1 are selectively required for the in vivo generation of CD4(+) memory T cells
  • POU2F1 and GATA3/POU2F2 direct Th2 cytokine gene expression in a cooperative manner
  • plays a critical role in CD4 T cells through regulating gene expression during differentiation and mediating long-range chromosomal interactions
  • has various functions in gene regulation
  • participates in carcinogenesis and cancer progression via promotion of cell proliferation and metastasis
  • is a DNA-binding transcription regulator and its level being highly increased in many human cancers
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the octamer motif AGTCAAAT
    RNA
    small molecule
    protein
  • interacting with p65
  • interacting with NR3C1, AR, PGR, HCFC1
  • interact with glycolytic enzymes in a complex which may act as a metabolic sensor (Shakya 2009)
  • POU2AF1 is a B lymphocyte-specific transcription factor which coactivates POU2F1 and POU2F2 on B cell specific promoters
  • PDCD1LG2 expression is regulated by two different promoters that function in a lineage-specific manner, with the B-1-specific promoter being constitutively active as a result of POU2F1 and POU2F2 binding
  • POU2F1 cooperates with the TATA binding initiation complex to control rapid transcription of NOS2
  • acts as a transcriptional repressor of CRP expression
  • POU2F1 integrates metabolic and stress signals via OGT modification to regulate target gene activity
  • POU2F1 regulates IL17A expression by directing interchromosomal associations in conjunction with CTCF in T cells
  • STAT2 and STAT4 are direct targets for POU2F1 protein
  • POU2F1 induced the expression of TWIST1, SNAI1, SNAI2 and ZEB1 genes which are involved in the regulation of epithelial-to-mesenchymal transition (EMT)
  • dynamic interplay between POU2F1 and POU2F5, in particular during the critical window immediately after loss of pluripotency when cells make the earliest developmental fate decisions
  • BRCA1 promotes oxidative metabolism by degrading POU2F1, a transcription factor with proglycolytic and tumorigenic effects.
  • cell & other
    REGULATION
    Other mitotic phosphorylation
    phosphorylated by PRKDC
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    promoted hepatocellular carcinoma cell proliferation, colony formation, migration, and invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    1 is a potential novel therapeutic target in HCC
    ANIMAL & CELL MODELS