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FLASH GENE
Symbol POU2F1 contributors: mct - updated : 04-02-2019
HGNC name POU class 2 homeobox 1
HGNC id 9212
Location 1q24.2      Physical location : 167.190.142 - 167.385.317
Synonym name
  • octamer-binding transcription factor 1
  • POU domain, class 2, transcription factor 1
  • Synonym symbol(s) OCT1, OTF1, NF-A1, FLJ42836
    DNA
    TYPE functioning gene
    STRUCTURE 206.52 kb     17 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 13905 - 766 expressed at a high level in the CD34+ hematopoetic progenitor cells 2018 30042821
  • OCT1L
  • 15 - 13716 - 703 - 2018 30042821
    16 - 14038 - 755 - 2018 30042821
    18 - 14342 - 741 - 2018 30042821
    17 - 14138 - 741 - 2018 30042821
    - - 1911 - 623 found in B cells, but not in hematopoetic progenitor cells 2018 30042821
  • is transcribed from the same promoter as Oct-1L
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Endocrineadrenal gland   highly
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Nervousbraindiencephalonepithalamushabenula 
     brainhindbrainmedulla oblongataarea postrema 
    cells
    SystemCellPubmedSpeciesStageRna symbol
     granular cell
    Nervousmammilary cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • POU specific and POU homeo (helix-turn-helix) domains
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Pou2f1 (93.8pc)
    homolog to rattus Pou2f1 (95.3pc)
    Homologene
    FAMILY
  • POU transcription factor family, class 2 subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • POU2F1 colocalizes with lamin B1 at the spindle poles and midbody
  • basic FUNCTION
  • transcription factor for small nuclear RNA and histone H2B genes
  • involved in the transcriptional repression of the gonadotropin-releasing hormone receptor gene(GNRHR)
  • repressing with its POU domain, the expression of E-selectin, vascular cell adhesion molecule (VCAM-1), two cytokine-inducible, NF-kappaB-dependent endothelial-leukocyte adhesion molecules that participate in the leukocyte recruitment phase of the inflammatory response
  • transactivating PTTG1 (Zhou 2008)
  • downstream effector of Notch signaling during radial glia formation (Kiyota 2008)
  • may have regulatory functions in prostate development and cancer progression (Jariwala 2009)
  • is phosphorylated in response to oxidative and genotoxic stress and is essential for a normal post-stress transcriptional response (Kang 2009)
  • POU2AF1 together with POU2F1/POU5F1, binds to octamer sites in promoters and enhancers to activate transcription of immunoglobulin (Ig) genes
  • a putative defect in POU2F1 and/or POU2F2, by affecting HMGA1 expression, may cause INSR dysfunction, leading to defects of the INSR signaling pathway
  • new role for POU2F1 in mesenchymal stem cells (hMSCs) aging
  • POU2F1 and POU2AF1 are selectively required for the in vivo generation of CD4(+) memory T cells
  • POU2F1 and GATA3/POU2F2 direct Th2 cytokine gene expression in a cooperative manner
  • plays a critical role in CD4 T cells through regulating gene expression during differentiation and mediating long-range chromosomal interactions
  • has various functions in gene regulation
  • participates in carcinogenesis and cancer progression via promotion of cell proliferation and metastasis
  • is a DNA-binding transcription regulator and its level being highly increased in many human cancers
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the octamer motif AGTCAAAT
    RNA
    small molecule
    protein
  • interacting with p65
  • interacting with NR3C1, AR, PGR, HCFC1
  • interact with glycolytic enzymes in a complex which may act as a metabolic sensor (Shakya 2009)
  • POU2AF1 is a B lymphocyte-specific transcription factor which coactivates POU2F1 and POU2F2 on B cell specific promoters
  • PDCD1LG2 expression is regulated by two different promoters that function in a lineage-specific manner, with the B-1-specific promoter being constitutively active as a result of POU2F1 and POU2F2 binding
  • POU2F1 cooperates with the TATA binding initiation complex to control rapid transcription of NOS2
  • acts as a transcriptional repressor of CRP expression
  • POU2F1 integrates metabolic and stress signals via OGT modification to regulate target gene activity
  • POU2F1 regulates IL17A expression by directing interchromosomal associations in conjunction with CTCF in T cells
  • STAT2 and STAT4 are direct targets for POU2F1 protein
  • POU2F1 induced the expression of TWIST1, SNAI1, SNAI2 and ZEB1 genes which are involved in the regulation of epithelial-to-mesenchymal transition (EMT)
  • dynamic interplay between POU2F1 and POU2F5, in particular during the critical window immediately after loss of pluripotency when cells make the earliest developmental fate decisions
  • BRCA1 promotes oxidative metabolism by degrading POU2F1, a transcription factor with proglycolytic and tumorigenic effects.
  • cell & other
    REGULATION
    Other mitotic phosphorylation
    phosphorylated by PRKDC
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    promoted hepatocellular carcinoma cell proliferation, colony formation, migration, and invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    1 is a potential novel therapeutic target in HCC
    ANIMAL & CELL MODELS