basic FUNCTION
| transcription factor for small nuclear RNA and histone H2B genes |
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involved in the transcriptional repression of the gonadotropin-releasing hormone receptor gene(GNRHR) |
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repressing with its POU domain, the expression of E-selectin, vascular cell adhesion molecule (VCAM-1), two cytokine-inducible, NF-kappaB-dependent endothelial-leukocyte adhesion molecules that participate in the leukocyte recruitment phase of the inflammatory response |
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transactivating PTTG1 (Zhou 2008) |
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downstream effector of Notch signaling during radial glia formation (Kiyota 2008) |
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may have regulatory functions in prostate development and cancer progression (Jariwala 2009) |
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is phosphorylated in response to oxidative and genotoxic stress and is essential for a normal post-stress transcriptional response (Kang 2009) |
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POU2AF1 together with POU2F1/POU5F1, binds to octamer sites in promoters and enhancers to activate transcription of immunoglobulin (Ig) genes |
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a putative defect in POU2F1 and/or POU2F2, by affecting HMGA1 expression, may cause INSR dysfunction, leading to defects of the INSR signaling pathway |
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new role for POU2F1 in mesenchymal stem cells (hMSCs) aging |
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POU2F1 and POU2AF1 are selectively required for the in vivo generation of CD4(+) memory T cells |
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POU2F1 and GATA3/POU2F2 direct Th2 cytokine gene expression in a cooperative manner |
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plays a critical role in CD4 T cells through regulating gene expression during differentiation and mediating long-range chromosomal interactions |
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has various functions in gene regulation |
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participates in carcinogenesis and cancer progression via promotion of cell proliferation and metastasis |
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is a DNA-binding transcription regulator and its level being highly increased in many human cancers |