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FLASH GENE
Symbol POTEB contributors: mct/npt - updated : 03-09-2009
HGNC name POTE ankyrin domain family, member B
HGNC id 33734
Location 15q11.2      Physical location : 21.040.700 - 22.083.137
Synonym name
  • protein expressed in prostate, ovary, testis, and placenta 15
  • ANKRD26-like family B, member 1
  • Synonym symbol(s) MGC119371, MGC119373, POTE15, POTE-15, A26B1, CT104.5
    DNA
    TYPE functioning gene
    STRUCTURE 31.28 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1706 61.1 544 - Bera (2004)
  • 111 bp shorter than POTE15A
  • exon 1 is 111 bp shorter
  • lack the three repeats at the N-terminus of the protein
  • 11 - 2132 65.7 581 - Bera (2004)
  • isoform A
  • deletion of nine bases in the last exon
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Lymphoid/Immunespleen    
    Nervousbrain    
    Reproductivemale systemprostate   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal three cysteine rich domain (CRD), palmitoylated on paired cysteine residues in each CRD motif (palmitoylation is responsible of the strong association with plasma membrane)
  • seven ankyrin repeats
  • spectrin-like helices
  • HOMOLOGY
    intraspecies paralog to POTED
    Homologene
    FAMILY
  • POTE family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing the release of fatty acids from phospholipids
  • may participate in FAS mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS